Thursday, August 25, 2011

Eltroxin Tablets | Generic Synthroid | Dosage | Uses | Side effects

Eltroxin Tablets (Generic Synthroid) - Active Ingredient And Chemical structure

The active ingredient contained in Eltroxin Tablets is Levothyroxine Sodium . The structure is shown below

Structure Of  Levothyroxine Sodium


Eltroxin (Generic Synthroid) - Uses

Generic Synthroid in the form of Eltroxin Tablets is used as replacement or supplemental therapy in congenital or acquired hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis.
Eltroxin is also used in the treatment or prevention of various types of euthyroid goiters, including thyroid nodules.


Generic Forms and Brand names of Synthroid

Eltroxin Tablets manufactured by GlaxoSmithKline, India is a hormone replacement medication usually given to patients with hypothyroidism and is also used to treat goiter. Synthroid which has the active ingredient Levothyroxine Sodium is also sold as Thyrax, Euthyrox, Levaxin, L-thyroxine, Eltroxin, Thyrax, Duotab, Thyrox, Eutirox, Tirosint, Levoxyl, Levothroid, Unithroid and under various other brand names.


Eltroxin (Generic Synthroid) - Preparations

Eltroxin (Generic Synthroid) is available as tablets of 50 mcg and 100 mcg. Eltroxin (levothyroxine sodium tablets) contains synthetic crystalline levothyroxine (T4) sodium. Synthetic T4 is identical to that produced in the human thyroid gland.


Eltroxin (Generic Synthroid) - Storage Requirements

Eltroxin Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.


Eltroxin Tablets - Dosage

Eltroxin is administered as a single daily dose, preferably one-half to one hour before breakfast. Eltroxin tablets should be swallowed whole, and taken with a full glass of water. Eltroxin tablets should not be split.
Eltroxin tablets should preferably be taken on an empty stomach. Eltroxin should be taken at least 4 hours apart from drugs that are known to interfere with its absorption. The average full replacement dose of levothyroxine sodium is approximately 1.7 mcg/kg/day (e.g., 100-125 mcg/day for a 70 kg adult). Older patients may require less than 1 mcg/kg/day. Please consult your doctor for exact dosing instructions. Dosage are individualized as per requirement of each patient.


Side Effects Of Eltroxin (Generic Synthroid)

The adverse effects of levothyroxine therapy are primarily those of hyperthyroidism due to therapeutic overdosage. The most common side effects are listed below:
General: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating;
Central nervous system: headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia;
Musculoskeletal: tremors, muscle weakness;
Cardiovascular: palpitations, tachycardia, arrythmias, increased pulse and blood pressure, heart failure, angina, myocardial infarction, cardiac arrest;
Respiratory: dyspnea;
Gastrointestinal: diarrhea, vomiting, abdominal cramps and elevations in liver function tests;
Dermatologic: hair loss, flushing;
Endocrine: decreased bone mineral density;
Reproductive: menstrual irregularities, impaired fertility.
Pseudotumor cerebri and slipped capital femoral epiphysis have been reported in children receiving levothyroxine therapy. Overtreatment may result in craniosynostosis in infants and premature closure of the epiphyses in children with resultant compromised adult height.
Seizures have been reported rarely with the institution of levothyroxine therapy.
Inadequate levothyroxine dosage will produce or fail to ameliorate the signs and symptoms of hypothyroidism.
Hypersensitivity Reactions:Hypersensitivity reactions to inactive ingredients have occurred in patients treated with thyroid hormone products. These include urticaria, pruritus, skin rash, flushing, angioedema, various GI symptoms (abdominal pain, nausea, vomiting and diarrhea), fever, arthralgia, serum sickness and wheezing. Hypersensitivity to levothyroxine itself is not known to occur.


Eltroxin Tablets - Contraidications

Eltroxin (Levothyroxine Sodium) is contraindicated in patients with untreated subclinical (suppressed serum TSH level with normal T3 and T4 levels) or overt thyrotoxicosis of any etiology and in patients with acute myocardial infarction. Eltroxin (Levothyroxine Sodium) is contraindicated in patients with uncorrected adrenal insufficiency since thyroid hormones may precipitate an acute adrenal crisis by increasing the metabolic clearance of glucocorticoids. Eltroxin is contraindicated in patients with hypersensitivity to Levothyroxine Sodium or any of the inactive ingredients in Eltroxin tablets.


Eltroxin Tablets - Overdosage And Overdose Symptoms

The signs and symptoms of overdosage Eltroxin Tablets of are those of hyperthyroidism . In addition, confusion and disorientation may occur. Cerebral embolism, shock, coma, and death have been reported. Seizures have occurred in a child ingesting approximately 18 mg of levothyroxine. Symptoms may not necessarily be evident or may not appear until several days after ingestion of levothyroxine sodium.


Further Information

Prescribing Information


Friday, August 19, 2011

Cipla Clopivas Tablets | Clopidogrel | Uses | Clopivas Side effects

Clopivas Tablets (Generic Plavix) - Active Ingredient And Chemical structure

The active ingredient contained in Clopivas Tablets is Clopidogrel Bisulfate. Clopidogrel bisulfate is a white to off-white powder which is practically insoluble in water. The structure is shown below
Structure of Clopidogrel Bisulfate


Clopivas Tablets (Clopidogrel) - Preparations

Clopivas Tablets are available as oral tablets of 75 mg . Each film coated tablet contains 75 mg of Clopidogrel Bisulfate


Generic Forms and Brand names of Plavix (Clopidogrel Bisulfate)

Clopivas manufactured by Cipla Ltd., India is an effective treatment for Acute Coronary Syndrome, Myocardial Infarction, Recent Stroke or Established Peripheral Arterial Disease. Generic Plavix which has the active ingredient Clopidogrel Bisulfate is also sold as Plagril tablets and under various other brand names.


Clopivas Tablets - Storage Requirements

Clopivas Tablets are to be stored at room temperature (15°C to 30°C) in a cool and dry place. Store away from heat, moisture, and light. Keep out of reach of children and pets.


Clopivas Tablets - Uses

Clopivas (Clopidogrel) is an inhibitor of platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y12 class of adenosine diphosphate (ADP) receptors on platelets. Clopivas used to treat:
Acute coronary syndrome
Patients with non-ST-segment elevation ACS
Patients with ST-elevation myocardial infarction (STEMI)
Recent myocardial infarction (MI), recent stroke, or established peripheral arterial disease.


Clopivas Tablets (Clopidogrel Bisulfate) - Dosage

Clopivas Tablets can be administered with or without food. The dosing for Clopivas Tablets is as follows:
Acute coronary syndrome
-For patients with Non-ST-segment elevation ACS (UA/NSTEMI): Initiate Clopivas (clopidogrel) with a single 300 mg oral loading dose followed by 75 mg once daily, in combination with aspirin (75-325 mg once daily)
-For patients with STEMI: The recommended dose of Clopivas (clopidogrel) is 75 mg once daily, in combination with aspirin (75-325 mg once daily), with or without a loading dose and with or without thrombolytics
Recent MI, recent stroke, or established peripheral arterial disease (PAD):The recommended dose of Clopivas is 75 mg once daily orally, with or without food.


Clopivas Tablets (Clopidogrel Bisulfate) - Contraindications

Clopivas Tablets is contraindicated in patients with active pathological bleeding such as peptic ulcer or intracranial hemorrhage. Clopivas Tablets are also contraindicated in patients with hypersensitivity to Clopidogrel Bisulfate or any any inactive ingredient of the product.


Side Effects Of Clopivas Tablets (Clopidogrel Bisulfate)

Clopivas is generally well tolerated. Side effects of Clopivas Tablets (Clopidogrel) that have been reported include bleeding, including life-threatening and fatal bleeding, thrombotic thrombocytopenic purpura (TTP), gastrointestinal hemorrhage, pruritus, chest pain, headache, upper respiratory tract infection, rash, edema and influenza like symptoms.


Further Information About Cipla Clopivas Tablets

Prescribing Information



Wednesday, August 17, 2011

Losacar Tablets | Generic Losartan | Dosage | Uses | Side effects

Losacar Tablets (Generic Losartan) - Active Ingredient And Chemical structure

Losacar (Losartan Potassium) is an angiotensin II receptor (type AT1) antagonist. Losartan Potassium is a white to off-white free-flowing crystalline powder which is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents. The structure is shown below
Structure Of Losartan


Generic Losartan (Losartan Potassium)- Uses

Generic Losartan in the form of Losacar Tablets is used for the treatment of hypertension. It is also used for the treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio =300 mg/g) in patients with type 2 diabetes and a history of hypertension.


Generic Forms and Brand names of Losartan (Losartan Potassium)

Losacar manufactured by Zydus Cadila, India is an effective treatment for hypertension. Losartan which has the active ingredient Losartan Potassium is also sold as Losacar-A, Hyzaar, Cozaar, Cosart and under various other brand names.


Losacar Tablets (Generic Losartan) - Preparations

The active ingredient contained in Losacar Tablets is losartan potassium. Losacar is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of Losartan Potassium


Losacar Tablets (Generic Losartan) - Storage Requirements

Losacar Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.


Losacar Tablets (Generic Losartan) - Dosage

For Adult Hypertensive Patients, the recommended starting dose of Losacar Tablets is 50 mg once daily, with 25 mg used in patients with possible depletion of intravascular volume (e.g., patients treated with diuretics) Dosing has to be individualized. Please consult your doctor for exact dosing instructions. Losacar Tablets may be administered with other antihypertensive agents, and with or without food.


Losacar Tablets (Generic Losartan) - Contraindications

Losacar is contraindicated in patients who are hypersensitive to any component of this product.


Side Effects Of Losacar Tablets (Losartan Potassium)

The most common side effects of Losacar Tablets (Losartan Potassium) are Cramps in muscle, Back Pain, LegPain, Dizziness, Nasal Congestion, Infection in upper respiratory tract, Sinusitis. Less common side effects that may occur are asthenia/fatigue, edema/swelling, abdominal pain, chest pain, nausea, headache, pharyngitis, diarrhea, dyspepsia, myalgia, insomnia, cough, sinus disorder.


Further Information

Prescribing Information