Risofos Tablets | Generic Actonel | Dosage | Uses | Side effects

Risofos Tablets (Generic Actonel) - Active Ingredient And Chemical structure

The active ingredient contained in Risofos Tablets is Risedronate Sodium. Risedronate sodium is a fine, white to off-white, odorless, crystalline powder. It is soluble in water and in aqueous solutions. The structure is shown below

Generic Actonel (Risofos Tablets) - Uses

Generic Actonel in the form of Risofos Tablets 35 mg is used for Treatment and prevention of postmenopausal osteoporosis, Treatment to increase bone mass in men with osteoporosis, Treatment and prevention of glucocorticoid-induced osteoporosis and Treatment of Paget's disease.
Postmenopausal Osteoporosis
Risofos is indicated for the treatment and prevention of osteoporosis in postmenopausal women.
Treatment of Osteoporosis
In postmenopausal women with osteoporosis, risedronate increases Bone Mass Density and reduces the incidence of vertebral fractures and a composite endpoint of nonvertebral osteoporosis-related fractures.
Prevention of Osteoporosis
Risofos may be considered in postmenopausal women who are at risk of developing osteoporosis and for whom the desired clinical outcome is to maintain bone mass and to reduce the risk of fracture.
Osteoporosis in Men
Risofos is indicated for treatment to increase bone mass in men with osteoporosis.
Glucocorticoid-Induced Osteoporosis
Risofos is indicated for the prevention and treatment of glucocorticoid-induced osteoporosis in men and women who are either initiating or continuing systemic glucocorticoid treatment (daily dosage equivalent to 7.5 mg or greater of prednisone) for chronic diseases. Patients treated with glucocorticoids should receive adequate amounts of calcium and vitamin D.
Paget`s Disease
Risofos is indicated for treatment of Paget`s disease of bone in men and women. Treatment is indicated in patients with Paget`s disease of bone
(1) who have a level of serum alkaline phosphatase at least 2 times the upper limit of normal, or
(2) who are symptomatic, or
(3) who are at risk for future complications from their disease, to induce remission (normalization of serum alkaline phosphatase).

Generic Forms and Brand names of Actonel

Risofos Tablets manufactured by Cipla Ltd., India is an effective treatment for treating and preventing osteoporosis in certain patients. Actonel which has the active ingredient Risedronate sodium is also sold as Atelvia, Benet and under various other brand names.

Risofos Tablets Preparations

Risofos is available as tablets of 35 mg. Each Risofos Tablet for oral administration contains the equivalent of 35 mg of anhydrous risedronate sodium in the form of the hemi-pentahydrate with small amounts of monohydrate.

Risofos Tablets - Storage Requirements

Risofos Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.

Risofos Tablets (Generic Actonel) - Dosage

Risofos Tablets should be taken at least 30 minutes before the first food or drink of the day other than water. To facilitate delivery to the stomach, Risofos Tablets (Generic Actonel) should be swallowed while the patient is in an upright position and with a full glass of plain water (6 to 8 oz).
Patients should not lie down for 30 minutes after taking the medication. Patients should receive supplemental calcium and vitamin D if dietary intake is inadequate. Calcium supplements and calcium-, aluminum-, and magnesium-containing medications may interfere with the absorption of Generic Actonel 35 mg and should be taken at a different time of the day.
Risofos is not recommended for use in patients with severe renal impairment (creatinine clearance less than 30 mL/min). No dosage adjustment is necessary in patients with a creatinine clearance greter than or equal to 30 mL/min or in the elderly.

Treatment and Prevention of Postmenopausal Osteoporosis
The recommended dosage is one 35 mg tablet orally, taken once a week.
Treatment to Increase Bone Mass in Men with Osteoporosis
The recommended dosage is One 35 mg tablet orally, taken once a week
Treatment and Prevention of Glucocorticoid -Induced Osteoporosis
The recommended dosage is One 35 mg tablet orally, taken once a week.
Paget`s Disease
The recommended dosage for treatment is 30 mg orally once daily for 2 months. Retreatment may be considered (following post-treatment observation of at least 2 months) if relapse occurs, or if treatment fails to normalize serum alkaline phosphatase. For retreatment, the dose and duration of therapy are the same as for initial treatment.

Risofos Tablets (Generic Actonel) - Contraindications

Risofos Tablets is contraindicated in the following cases:
Hypocalcemia, Known hypersensitivity to Risedronate Sodium or any inactive component of this medication and Inability to stand or sit upright for at least 30 minutes.

Side Effects Of Risofos Tablets (Generic Actonel)

The most common side effects of Generic Actonel are back pain, arthralgia, myalgia, abdominal pain, nausea, and dyspepsia. Rare side effects that may occur are Hypersensitivity reactions (angioedema, generalized rash, bullous skin reactions), and eye inflammation (iritis, uveitis).

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Osteofos Tablets | Generic Fosamax | Dosage | Uses | Side effects

Osteofos Tablets (Generic Fosamax) - Active Ingredient And Chemical structure

The active ingredient contained in Osteofos Tablets is Alendronate Sodium. Alendronate sodium is a white, crystalline, nonhygroscopic powder. It is soluble in water, very slightly soluble in alcohol, and practically insoluble in chloroform. The structure is shown below

Generic Forms and Brand names of Fosamax

Osteofos Tablets manufactured by Cipla Ltd., India is used for treatment and prevention of osteoporosis in postmenopausal women. Fosamax which has the active ingredient Alendronate Sodium is also sold under various other brand names.

Osteofos Tablets Preparations

Osteofos is available as tablets of 10 mg, 35 mg and 70 mg . Each uncoated tablet of Osteofos for oral administration contains Sodium Alendronate BP equivalent to Alendronic acid 10 mg, 35 mg and 70 mg respectively as well as inactive ingredients.

Osteofos Tablets - Storage Requirements

Osteofos Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.

Generic Fosamax (Osteofos Tablets) - Uses

Generic Fosamax in the form of Osteofos Tablets is used for:
Treatment and prevention of osteoporosis in postmenopausal women
For the treatment of osteoporosis, Generic Fosamax increases bone mass and reduces the incidence of fractures, including those of the hip and spine (vertebral compression fractures).
Osteoporosis may be confirmed by the finding of low bone mass or by the presence or history of osteoporotic fracture.
For the prevention of osteoporosis , Osteofos Tablets may be considered in postmenopausal women who are at risk of developing osteoporosis and for whom the desired clinical outcome is to maintain bone mass and to reduce the risk of future fracture.
Treatment to increase bone mass in men with osteoporosis
Treatment of glucocorticoid-induced osteoporosis in men and women receiving glucocorticoids in a daily dosage equivalent to 7.5 mg or greater of prednisone and who have low bone mineral density. Patients treated with glucocorticoids should receive adequate amounts of calcium and vitamin D.
Treatment of Paget’s disease of bone in men and women
Treatment is indicated in patients with Paget's disease of bone having alkaline phosphatase at least two times the upper limit of normal, or those who are symptomatic, or those at risk for future complications from their disease.

Osteofos Tablets - Contraindications

Osteofos Tablets (Generic Fosamax) is contraindicated in the following cases:

• Abnormalities of the esophagus which delay esophageal emptying such as stricture or achalasia


• Inability to stand or sit upright for at least 30 minutes


• Hypersensitivity to Alendronate Sodium or any inactive ingredient of this medication.


• Hypocalcemia

Osteofos Tablets - Dosage

Osteofos Tablets must be taken at least half an hour before the first food, beverage, or medication of the day with plain water only. Other beverages (including mineral water), food, and some medications are likely to reduce the absorption of Osteofos. Waiting less than 30 minutes, or taking Osteofos with food, beverages (other than plain water) or other medications will lessen the effect of Osteofos by decreasing its absorption into the body.
Generic Fosamax should only be taken upon arising for the day. To facilitate delivery to the stomach and thus reduce the potential for esophageal irritation, an Osteofos tablet should be swallowed with a full glass of water (6-8 oz). Patients should not lie down for at least 30 minutes and until after their first food of the day. Osteofos should not be taken at bedtime or before arising for the day.
Failure to follow these instructions may increase the risk of esophageal adverse experiences Patients should receive supplemental calcium and vitamin D, if dietary intake is inadequate No dosage adjustment is necessary for the elderly or for patients with mild-to-moderate renal insufficiency (creatinine clearance 35 to 60 mL/min). Osteofos is not recommended for patients with more severe renal insufficiency (creatinine clearance less than 35 mL/min) due to lack of experience.
The recommended dosage of Osteofos for the treatment of various indications is given below:
Treatment of osteoporosis in postmenopausal women
The recommended dosage is:
• one 70 mg tablet once weekly
or
• one 10 mg tablet once daily
Treatment to increase bone mass in men with osteoporosis
The recommended dosage is:
• one 70 mg tablet once weekly
or
• one 10 mg tablet once daily
Prevention of osteoporosis in postmenopausal women
The recommended dosage is:
• one 35 mg tablet once weekly
or
one 5 mg tablet once daily
The safety of treatment and prevention of osteoporosis with Osteofos has been studied for up to 7 years.
Treatment of glucocorticoid-induced osteoporosis in men and women
The recommended dosage is one 5 mg tablet once daily, except for postmenopausal women not receiving estrogen, for whom the recommended dosage is one 10 mg tablet once daily.
Paget’s disease of bone in men and women
The recommended treatment regimen is 40 mg once a day for six months.
Retreatment of Paget’s disease
In clinical studies in which patients were followed every six months, relapses during the 12 months following therapy occurred in 9% (3 out of 32) of patients who responded to treatment with Osteofos.

Side Effects Of Osteofos Tablets (Generic Fosamax)

The most common side effects of are given below:
Gastrointestinal
abdominal pain, nausea, dyspepsia, constipation, diarrhea, flatulence, acid regurgitation, esophageal ulcer, vomiting, dysphagia, abdominal distention and gastritis
Musculoskeletal
musculoskeletal (bone, muscle or joint) pain, muscle cramp
Nervous System/Psychiatric
headache, dizziness
Special Senses
taste perversion
Rarely, rash and erythema have occurred.

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Tugain Foam | Generic Rogaine | Dosage | Uses | Side effects

Tugain Foam (Generic Rogaine) - Active Ingredient And Chemical structure

The active ingredient contained in Tugain Foam is Minoxidil. The structure is shown below

Generic Rogaine (Minoxidil) - Uses

Generic Rogaine (Minoxidil) in the form of Tugain Foam 5% is used to treat androgenic alopecia only in men.

Generic Forms and Brand names of Rogaine (Minoxidil)

Tugain Foam manufactured by Cipla Ltd., India is an effective treatment to stimulate hair growth and to slow balding. Rogaine which has the active ingredient Minoxidil is also sold as Regaine, Vanarex, Mintop and Loniten (oral), and Avacor Physician's Formulation and under various other brand names.

Tugain Foam (Minoxidil) - Preparations

Tugain Foam (Generic Rogaine) is available as cans of 60 grams.

Tugain Foam (Minoxidil) - Storage Requirements

Tugain Foam (Minoxidil) is to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.

Tugain Foam (Generic Rogaine) - Dosage

Tugain Foam is for external use only and should be used only as directed. Tugain Foam should be prevented from getting into your eyes, nose, or mouth. Do not swallow the medication. Apply Tugain Foam only when the hair and scalp are clean and dry.
Apply half a capful of Tugain Foam twice daily at 12-hour intervals to the scalp, beginning at the centre of the affected area and spreading the foam out to cover the entire affected area.
Each can of Generic Rogaine should last one month, if used as directed.
In order to obtain the best results, Tugain Foam should be allowed to remain on the scalp for about 4 hours before washing. The night-time application should be done 2-4 hours before going to bed to allow the medication to dry out.
Tugain Foam should be massaged gently into the scalp. A hair dryer should not be used to speed up the drying of the foam as it may decrease the effectiveness. Tugain Foam should not be mixed with any hair oil. The medicine should not be used more frequently than two times a day, or be taken orally or applied to any other part of the body to avoid the risk of adverse effects and unwanted hair growth. Using Tugain Foam more frequently or longer application time have no effect on hair growth. In case you miss any daily applications of Tugain Foam, the patient should continue with the next dose. Do not double your dose.
Wash your hands immediately after the application of Tugain Foam. Clinical experience with minoxidil (Generic Rogaine) shows that twice-daily applications for 4 months or more may be required before there is evidence of hair growth. To arrest hair fall, the medication should be used for 45 days or more. In case you stop taking the medication, most new hair that is gained will be lost within a few months after Generic Rogaine is stopped.

Tugain Foam (Generic Rogaine) - Contraindications

Tugain Foam (Generic Rogaine) is contraindicated in the following circumstances:

• Patients with a history of hypersensitivity any of the ingredients present in the medication.


• Patients with cardiac abnormalities.


• Children below 18 years of age, pregnant women and nursing mothers.


• Patients in whom the reason for hair loss is unknown.


• Patients using occlusive dressings or other medicines on the scalp.


• On a shaved scalp


• In patients whic have sudden and/or patchy hair loss.


• Patients with red, inflamed infection, or irritated or painful scalp (including psoriasis and sunburn).


• Patients with hypovolemic states (e.g., co-treatment with diuretics, dehydration, etc.)

Side Effects Of Tugain Foam (Generic Rogaine)

The most common side effects of minoxidil (Generic Rogaine) include burning or irritation of the eye, itching, redness or irritation at the treated area, as well as unwanted hair growth elsewhere on the body. Patients should stop treatment with Tugain Foam and seek medical attention immediately if they experience any of the following serious side effects: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; dizziness; fainting; fast heartbeat; sudden, unexplained weight gain; swollen hands or feet.