Isotroin Capsules | Generic Accutane | Dosage | Uses | Side effects

Isotroin Capsules (Generic Accutane) - Active Ingredient And Chemical structure

The active ingredient contained in Isotroin Capsules is Isotretinoin. Isotretinoin, a retinoid, is a yellow to orange crystalline powder with a molecular weight of 300.44. It is available as Isotroin Capsules (Generic Accutane) in 10 mg and 20 mg capsules for oral administration.The structure is shown below

Isotroin Capsules - Uses

Accutane in the form of Isotroin Capsules is used for the treatment of severe recalcitrant nodular acne. Nodules are inflammatory lesions with a diameter of 5 mm or greater. The nodules may become suppurative or hemorrhagic.

Generic Forms and Brand names of Accutane

Isotroin Capsules manufactured by Cipla Ltd., India is an effective treatment for moderate to severe acne that has failed other therapies. Accutane which has the active ingredient Isotretinoin is also sold as Sotret, Claravis, Amnesteem, Roaccutane, Clarus, Decutan, Isotane, Izotek, Oratane, Isotret and under various other brand names.

Isotroin Capsules - Preparations

Isotroin Capsules (Generic Accutane) is available as tablets of 10 mg and 20 mg.

Isotroin Capsules - Storage Requirements

Isotroin Capsules are to be stored at controlled room temperature (15°C to 30°C). Protect from light. Store away from heat and moisture.

Isotroin Capsules (Generic Accutane) - Contraindications

Isotroin Capsules (Generic Accutane) is contraindicated in patients who are hypersensitive to Isotretinoin or any inactive ingredient present in this medication. Generic Accutane should not be given to patients who are sensitive to parabens, which are used as preservatives in the gelatin capsule.

Isotroin Capsules (Generic Accutane) - Warnings

Isotroin Capsules (Generic Accutane) must not be used by female patients who are or may become pregnant. There is an extremely high risk that severe birth defects will result if pregnancy occurs while taking Accutane in any amount, even for short periods of time. Potentially any fetus exposed during pregnancy can be affected. There are no accurate means of determining whether an exposed fetus has been affected.
As there are significant adverse effects associated with its use, Isotroin Capsules should be reserved for patients with severe nodular acne who are unresponsive to conventional therapy, including systemic antibiotics.

Isotroin Capsules (Generic Accutane) - Dosage

Generic Accutane should always be administered with a meal. The recommended dosage range for Isotroin Capsules is 0.5 to 1.0 mg/kg/day given in two divided doses with food for 15 to 20 weeks.
In studies which compared 0.1, 0.5, and 1.0 mg/kg/day, it was found that all dosages provided initial clearing of the disease, but there was a greater need for retreatment with the lower dosages. During treatment, the Generic Accutane dose may be adjusted according to response of the disease and/or the appearance of clinical side effects — some of which may be dose related.

Side Effects Of Isotroin Capsules (Generic Accutane)

The most common side effects of Isotroin Capsules are listed below:
Body as a Whole
allergic reactions, including vasculitis, systemic hypersensitivity, edema, fatigue, lymphadenopathy, weight loss
Cardiovascular
palpitation, tachycardia, vascular thrombotic disease, stroke
Endocrine/Metabolic
hypertriglyceridemia, alterations in blood sugar levels
Gastrointestinal
inflammatory bowel disease, hepatitis, pancreatitis, bleeding and inflammation of the gums, colitis, esophagitis/esophageal ulceration, ileitis, nausea, other nonspecific gastrointestinal symptoms
Hematologic
allergic reactions, anemia, thrombocytopenia, neutropenia, rare reports of agranulocytosis.
Musculoskeletal
skeletal hyperostosis, calcification of tendons and ligaments, premature epiphyseal closure, decreases in bone mineral density, musculoskeletal symptoms including back pain, myalgia, and arthralgia, transient pain in the chest, arthritis, tendonitis, other types of bone abnormalities, elevations of CPK/rare reports of rhabdomyolysis.
Neurological
pseudotumor cerebri, dizziness, drowsiness, headache, insomnia, lethargy, malaise, nervousness, paresthesias, seizures, stroke, syncope, weakness
Psychiatric
suicidal ideation, suicide attempts, suicide, depression, psychosis, aggression, violent behaviors, emotional instability
Reproductive System
abnormal menses
Respiratory
bronchospasms (with or without a history of asthma), respiratory infection, voice alteration
Skin and Appendages
acne fulminans, alopecia (which in some cases persists), bruising, cheilitis (dry lips), dry mouth, dry nose, dry skin, epistaxis, eruptive xanthomas, erythema multiforme, flushing, fragility of skin, hair abnormalities, hirsutism, hyperpigmentation and hypopigmentation, infections (including disseminated herpes simplex), nail dystrophy, paronychia, peeling of palms and soles, photoallergic/photosensitizing reactions, pruritus, pyogenic granuloma, rash (including facial erythema, seborrhea, and eczema), Stevens-Johnson syndrome, sunburn susceptibility increased, sweating, toxic epidermal necrolysis, urticaria, vasculitis (including Wegener’s granulomatosis), abnormal wound healing
Hearing
hearing impairment, tinnitus.
Vision
corneal opacities, decreased night vision which may persist, cataracts, color vision disorder, conjunctivitis, dry eyes, eyelid inflammation, keratitis, optic neuritis, photophobia, visual disturbances
Urinary System
glomerulonephritis, nonspecific urogenital findings

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Montair Tablets | Generic Singulair | Dosage | Uses | Side effects

Montair Tablets (Generic Singulair)- Active Ingredient And Chemical structure

The active ingredient contained in Montair Tablets is Montelukast Sodium . Montelukast sodium is a hygroscopic, optically active, white to off-white powder. Montelukast sodium is freely soluble in ethanol, methanol, and water. The structure is shown below

Montair Tablets (Generic Singulair) - Uses

Generic Singulair in the form of Montair Tablets is used to treat the following indications:
(1) Treatment of asthma in adults and pediatric patients 12 months of age and older.
(2)Prevention of exercise-induced bronchoconstriction in patients 15 years of age and older.
(3)Relief of symptoms of allergic rhinitis (seasonal allergic rhinitis in adults and pediatric patients 2 years of age and older, and perennial allergic rhinitis in adults and pediatric patients 6 months of age and older).

Generic Forms and Brand names of Singulair

Montair manufactured by Cipla Ltd., India is an effective treatment for asthma, exercise induced bronchospasm, allergic rhinitis, and urticaria. Singulair which has the active ingredient Montelukast Sodium is also sold under various other brand names.

Montair Tablets - Preparations

Montair is available as tablets of 5 mg and 10 mg . Each film coated tablet contains 5 mg or 10 mg Montelukast Sodium respectively.

Montair Tablets (Generic Singulair) - Storage Requirements

Montair Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.

Montair Tablets (Generic Singulair) - Contraindications

Montair Tablets (Generic Singulair) are contraindicated in patients that have hypersensitivity to Montelukast sodium or any inactive ingredient of this product.

Montair Tablets (Generic Singulair) - Dosage

The dosage of Montair tablets for various indications is given below
Asthma: Once daily in the evening for patients 12 months and older.
Acute prevention of EIB : 10 mg tablet at least 2 hours before exercise for patients 15 years of age and older.
Seasonal allergic rhinitis : Once daily for patients 2 years and older.
Perennial allergic rhinitis: Once daily for patients 6 months and older.

Side Effects Of Montair Tablets (Generic Singulair)

The most common side effects of are Most common adverse reactions (incidence equal to and greater than 5% are upper respiratory infection, fever, headache, pharyngitis, cough, abdominal pain, diarrhea, otitis media, influenza, rhinorrhea, sinusitis, otitis.

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Emeset Tablets | Generic Zofran | Dosage | Uses | Side effects

Emeset Tablets (Generic Zofran) - Active Ingredient And Chemical structure

The active ingredient contained in Emeset Tablets is Ondansetron HCl. Ondansetron HCl dihydrate is a white to off-white powder that is soluble in water and normal saline. The structure is shown below

Generic Zofran (Emeset Tablets) - Uses

Generic Zofran in the form of Emeset Tablets is used for the following Indications:
1.Prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy, including cisplatin = 50 mg/m2.
2. Prevention of nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy.
3. Prevention of nausea and vomiting associated with radiotherapy in patients receiving either total body irradiation, single high-dose fraction to the abdomen, or daily fractions to the abdomen.
4. Prevention of postoperative nausea and/or vomiting. As with other medications used to prevent vomiting and nausea, routine prophylaxis is not recommended for patients in whom there is little expectation that nausea and/or vomiting will occur postoperatively. In patients where nausea and/or vomiting must be avoided postoperatively, ondansetron tablets and syrup is recommended even when the incidence of postoperative nausea and/or vomiting is low.

Generic Forms and Brand names of Zofran

Emeset Tablets manufactured by Cipla Ltd., India is an effective treatment for the prevention of nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy or radiation). Zofran which has the active ingredient Ondansetron HCl is also sold as Zuplenz, Emetron, Emodan, Ondemet, Setronax, Ondavell and under various other brand names.

Emeset Tablets Preparations

Emeset is available as tablets of 4 mg and 8 mg . Each film coated tablet contains Ondansetron hydrochloride dihydrate Equivalent to Ondansetron 4 mg and 8 mg respectively.

Emeset Tablets - Storage Requirements

Emeset Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.

Emeset Tablets - Dosage

Prevention of Nausea and Vomiting Associated With Highly Emetogenic Cancer Chemotherapy: The recommended adult oral dosage of Emeset Tablets is 24 mg given as three 8-mg tablets administered 30 minutes before the start of single-day highly emetogenic chemotherapy, including cisplatin = 50 mg/m2.
Prevention of Nausea and Vomiting Associated With Moderately Emetogenic Cancer Chemotherapy: The recommended adult oral dosage is one 8 mg Emeset Tablet given twice a day. The first dose should be administered 30 minutes before the start of emetogenic chemotherapy, with a subsequent dose 8 hours after the first dose. One 8 mg Emeset Tablet should be administered twice a day (every 12 hours) for 1 to 2 days after completion of chemotherapy. For pediatric patients 12 years of age and older, the dosage is the same as for adults. For pediatric patients 4 through 11 years of age, the dosage is one 4-mg Emeset Tablet given 3 times a day. The first dose should be administered 30 minutes before the start of emetogenic chemotherapy, with subsequent doses 4 and 8 hours after the first dose. One 4 mg Emeset Tablet should be administered 3 times a day (every 8 hours) for 1 to 2 days after completion of chemotherapy.
Prevention of Nausea and Vomiting Associated With Radiotherapy, Either Total Body Irradiation, or Single High-Dose Fraction or Daily Fractions to the Abdomen: The recommended oral dosage for adults is one 8 mg Emeset Tablet given 3 times a day.
For total body irradiation, one 8-mg Emeset Tablet should be administered 1 to 2 hours before each fraction of radiotherapy administered each day.
For single high-dose fraction radiotherapy to the abdomen, one 8-mg Emeset Tablet should be administered 1 to 2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for 1 to 2 days after completion of radiotherapy.
For daily fractionated radiotherapy to the abdomen, one 8-mg Emeset Tablet should be administered 1 to 2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for each day radiotherapy is given.
Postoperative Nausea and Vomiting: The recommended dosage is 16 mg given as two 8 mg Emeset Tablets 1 hour before induction of anesthesia.

Emeset Tablets - Contraindications

The concomitant use of apomorphine with ondansetron is contraindicated based on reports of profound hypotension and loss of consciousness when apomorphine was administered with ondansetron. Emeset Tablets are contraindicated for patients known to have hypersensitivity to Ondansetron HCl or any inactive ingredient present in the medication.

Emeset Tablets - Overdosage

There is no specific antidote for ondansetron overdose. Patients should be managed with appropriate supportive therapy. Individual intravenous doses as large as 150 mg and total daily intravenous doses as large as 252 mg have been inadvertently administered without significant adverse events. These doses are more than 10 times the recommended daily dose.

Side Effects Of Emeset Tablets (Generic Zofran)

The most common side effects of are Headache, Diarrhea, Malaise/fatigue,
Constipation and Dizziness.

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