Tegrital Tablets | Generic Tegretol | Carbamazepine | Dosage | Uses | Side effects

Tegrital Tablets (Generic Tegretol ) - Active Ingredient And Chemical structure

The active ingredient contained in Generic Tegretol is Carbamazepine. Carbamazepine is a white to off-white powder, which is practically insoluble in water and soluble in alcohol and in acetone.The structure is shown below

Generic Tegretol (Carbamazepine) - Uses

Carbamazepine in the form of Generic Tegretol Tablets (Tegrital Tablets) is used to treat certain types of epileptic seizures and treats episodes of severe pain in the face originating from the trigeminal nerve (trigeminal neuralgia).

Generic Forms and Brand names of Tegretol (Carbamazepine)

Tegrital (Carbamazepine) manufactured by Novartis, India is an anticonvulsant and specific analgesic (treatment of the pain) for trigeminal neuralgia ( nerve disorder which causes intermittent severe pain in parts of the face). Tegretol which has the active ingredient Carbamazepine is also sold as Zeptol, Biston, Calepsin, Carbatrol, Epitol, Finlepsin and under various other brand names.

Tegrital Tablets (Generic Tegretol) - Preparations

Tegrital Tablets (Carbamazepine) is available as tablets of 200 mg for oral administration.

Tegrital Tablets (Generic Tegretol) - Storage Requirements

Tegrital Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.

Tegrital Tablets - Contraindications

Tegrital Tablets (Carbamazepine) should not be used in patients that have a history of previous bone marrow depression. It is also contraindicated in persons with a hypersensitivity to Carbamazepine or any other inactive ingredient of the medication, or known sensitivity to any of the tricyclic compounds, such as amitriptyline, desipramine, imipramine, protriptyline, nortriptyline, etc. It's concurrent use with monoamine oxidase inhibitors is not recommended. MAO inhibitors should be discontinued for a minimum of 14 days (or more, if possible) before administration of Generic Tegretol.

Tegrital Tablets - Dosage

The recommended dosage for Tegrital Tablets (Generic Tegretol) is given below:
Epilepsy :
Adults and children over 12 years of age: The Initial Dosage for Tegrital tablets is 200 mg twice a day. This may be increased at weekly intervals by adding up to 200 mg/day using a twice a day regimen of Tegretol until the optimal response is obtained.
Trigeminal Neuralgia:
Initial Adult Dosage: On the first day, 100 mg twice a day for Tegrital tablets for a total daily dose of 200 mg. This daily dose may be increased by up to 200 mg/day using increments of 100 mg every 12 hours for tablets only as required to achieve freedom from pain. Do not exceed 1200 mg daily.

Side Effects Of Tegrital Tablets (Carbamazepine)

The most common side effects of Tegrital Tablets particularly observed during the initial phases of therapy, are dizziness, drowsiness, unsteadiness, nausea, and vomiting. Inorder to minimize the possibility of such reactions, Tegrital therapy should be initiated at the lowest dosage recommended. Aplastic Anemia and Agranulocytosis have been reported in association with the use of Generic Tegretol. Less common side effects that may occur are:
Hemopoietic System: Aplastic anemia, agranulocytosis, pancytopenia, bone marrow depression, thrombocytopenia, leukopenia, leukocytosis, eosinophilia, acute intermittent porphyria.
Skin: Pruritic and erythematous rashes, urticaria, toxic epidermal necrolysis (Lyell's syndrome) , Stevens-Johnson syndrome, photosensitivity reactions, alterations in skin pigmentation, exfoliative dermatitis, erythema multiforme and nodosum, purpura, aggravation of disseminated lupus erythematosus, alopecia, and diaphoresis. In certain cases, discontinuation of therapy may be necessary.
Cardiovascular System: Congestive heart failure, edema, aggravation of hypertension, hypotension, syncope and collapse, aggravation of coronary artery disease, arrhythmias and AV block, thrombophlebitis, thromboembolism, and adenopathy or lymphadenopathy.
Liver: Abnormalities in liver function tests, cholestatic and hepatocellular jaundice, hepatitis; very rare cases of hepatic failure.
Pancreatic: Pancreatitis.
Respiratory System: Pulmonary hypersensitivity characterized by fever, dyspnea, pneumonitis, or pneumonia.
Genitourinary System: Urinary frequency, acute urinary retention, oliguria with elevated blood pressure, azotemia, renal failure, and impotence. Albuminuria, glycosuria, elevated BUN, and microscopic deposits in the urine have also been reported.
Nervous System: Dizziness, drowsiness, disturbances of coordination, confusion, headache, fatigue, blurred vision, visual hallucinations, transient diplopia, oculomotor disturbances, nystagmus, speech disturbances, abnormal involuntary movements, peripheral neuritis and paresthesias, depression with agitation, talkativeness, tinnitus, and hyperacusis.
Digestive System: Nausea, vomiting, gastric distress and abdominal pain, diarrhea, constipation, anorexia, and dryness of the mouth and pharynx, including glossitis and stomatitis.
Eyes: Scattered punctate cortical lens opacities, as well as conjunctivitis, have been reported. Although a direct causal relationship has not been established, many phenothiazines and related drugs have been shown to cause eye changes.
Musculoskeletal System: Aching joints and muscles, and leg cramps.
Metabolism: Fever and chills. Inappropriate antidiuretic hormone (ADH) secretion syndrome has been reported. Cases of frank water intoxication, with decreased serum sodium (hyponatremia) and confusion, have been reported in association with Tegretol use.

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Cabgolin Tablets | Generic Dostinex | Cabergoline | Dosage | Uses | Side effects

Cabgolin Tablets (Generic Dostinex) - Active Ingredient And Chemical structure

The active ingredient contained in Cabgolin Tablets is cabergoline, a dopamine receptor agonist. Cabergoline is a white powder that is soluble in ethyl alcohol, chloroform, and N, Ndimethylformamide (DMF). It is slightly soluble in 0.1N hydrochloric acid and insoluble in water. Cabgolin Tablets, for oral administration, contain 0.5 mg of cabergoline. The structure is shown below

Generic Forms and Brand names of Dostinex

Cabgolin Tablets manufactured by Sun Pharmaceuticals Ltd., India is an effective treatment for disorders associated with high prolactin levels. Dostinex which has the active ingredient cabergoline is also sold as Cabaser and under various other brand names.

Cabgolin Tablets (Generic Dostinex) - Preparations

Cabgolin Tablets is available as tablets of 0.5 mg.

Cabgolin Tablets (Generic Dostinex) - Storage Requirements

Cabgolin Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.

Cabgolin Tablets(Generic Dostinex) - Uses

Cabergoline in the form of Cabgolin Tablets is used for the treatment of hyperprolactinemic disorders, either idiopathic or due to pituitary adenomas. Cabergoline is also used as an adjunctive therapy of prolactin-producing pituitary gland tumors.

Cabgolin Tablets (Generic Dostinex) - Dosage

The recommended starting dosage of Cabgolin Tablets is 0.25 mg twice a week. Dosage may be increased by 0.25 mg twice weekly up to a dosage of 1 mg twice a week according to the patient’s serum prolactin level. Before sarting treatment with Cabgolim , cardiovascular evaluation should be performed and echocardiography should be considered to assess for valvular disease.
Dosage increases should not occur more frequently than every 4 weeks, so that the doctor can assess the patient’s response to each dosage level. If the patient does not respond adequately, and no additional benefit is observed with higher doses of Cabgolin, the lowest dose that achieved maximal response should be used.

Cabgolin Tablets (Generic Dostinex) - Contraindications

Cabgolin Tablets are contraindicated in patients with:
Uncontrolled hypertension or known hypersensitivity to ergot derivatives.
Hypersensitivity to Cabergoline or any inactive conponent of the medication.
History of cardiac valvular disorders, as suggested by anatomical evidence of valvulopathy of any valve, determined by pre-treatment evaluation including echocardiographic demonstration of valve leaflet thickening, valve restriction, or mixed valve restriction-stenosis.
History of pulmonary, pericardial, or retroperitoneal fibrotic disorders.

Cabgolin Tablets (Generic Dostinex) - Interactions

Cabgolin Tablets (Cabergoline) should not be administered concurrently with D2antagonists, such as phenothiazines, butyrophenones, thioxanthenes, or metoclopramide.

Side Effects Of Cabgolin Tablets (Generic Dostinex)

The most common side effects of Cabgolin Tablets are Nausea, Constipation, Abdominal pain, Dyspepsia, Vomiting, Headache, Dizziness, Paresthesia, Vertigo, Asthenia, Fatigue, Hot flashes, Somnolence, Depression, Nervousness, Postural hypotension, Breast pain, Dysmenorrhea and abnormal vision.

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Flonida Cream | Generic Carac | Fluorouracil | Dosage | Uses | Side effects

Flonida Cream (Generic Carac) - Active Ingredient And Chemical structure

Flonida (Fluorouracil) 1% and 5% Topical Cream is an antineoplastic/antimetabolite medication for dermatological use. The active ingredient contained in Flonida Cream is Fluorouracil. It is sparingly soluble in water and slightly soluble in alcohol. The structure is shown below

Generic Forms and Brand names of Fluorouracil Cream (Generic Carac)

Flonida Cream manufactured by Shalaks, India is an effective treatment for for the topical treatment of multiple actinic (solar) keratoses. Carac Cream which has the active ingredient Fluorouracil is also sold as Fluorouracil Topical, Efudex, Fluoroplex and under various other brand names.

Flonida Cream - Preparations

Flonida Cream is available as 10 g tubes of 1% and 5% concentration.

Flonida Cream (Fluorouracil) - Uses

Fluorouracil in the form of Flonida Cream is used for the topical treatment of multiple actinic or solar keratoses of the face and anterior scalp. It is also used to treat other conditions such as basal cell carcinomas of the skin, Bowen's disease (a type of skin cancer), psoriasis, genital warts and porokeratosis (an unusual inherited skin condition causing dry patches on the arms and legs).

Flonida Cream - Storage Requirements

Flonida Cream is to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light. Keep out of the reach of children and pets.

Flonida Cream (Generic Carac) - Warninngs and Precautions

There exists the possibility for a delayed hypersensitivity reaction to Fluorouracil Cream. Hence patch testing for hypersensitivity may be inconclusive. The patient should avoid prolonged exposure to sunlight or any other forms of ultraviolet irradiation during treatment with Flonida Cream, as the intensity of the reaction may be increased.
Possibility exists of increased absorption through ulcerated or inflamed skin. Flonida Cream has to be applied with care near the eyes, nose, and mouth. Excessive reaction may occur in these areas due to irritation from accumulation of the medication. Flonida Cream is applied with the fingers, and the hands should be washed thouroughly soon afterwards. Patients should discontinue therapy with Fluorouracil Cream if symptoms of DPD enzyme deficiency develop. In rare cases, unexpected, systemic toxicity (e.g. stomatitis, diarrhea, neutropenia, and neurotoxicity) associated with parenteral administration of fluorouracil has been attributed to deficiency of DihydroPyrimidine Dehydrogenase "DPD" activity.

Flonida Cream (Fluorouracil) - Overdosage

Normally, overdosage of Flonida Cream will not cause acute problems. If Flonida Cream accidentally comes in contact with the eyes, flush the eyes with water or normal saline. If Flonida Cream is accidentally ingested, induce emesis and gastric lavage.

Flonida Cream (Generic Carac) - Dosage

Clean the affected area properly and wait 10 minutes before applying Flonida Cream (Generic Carac). Sufficient quantity of the medication has to be applied to cover the entire face or any other affected areas. Avoid contact with the eyes, eyelids, nostrils, and mouth. Apply the medication twice daily with fingertips and wash hands immediately afterwards. Normally a treatment period of two to six weeks is usually required. Increasing the frequency of application and a longer period of administration with Flonida Cream may be required on areas other than the head and neck.

Flonida Cream (Generic Carac) - Contraindications

Fluorouracil, the active ingredient in Flonida Cream may cause fetal harm when administered to a pregnant woman. Hence, Flonida Cream (Generic Carac) is contraindicated in women who are or may become pregnant. This medication should not be used by patients who are allergic to Fluorouracil or to any of the inactive components present in Flonida Cream.

Side Effects Of Flonida Cream (Fluorouracil Cream)

The most common side effects of are Pain, Pruritus, Burning, Irritation, Inflammation, allergic contact dermatitis and telangiectasia. Rarely, hyperpigmentation and scarring have also been reported.

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