Cabgolin Tablets (Generic Dostinex) - Active Ingredient And Chemical structure
The active ingredient contained in Cabgolin Tablets is cabergoline, a dopamine receptor agonist. Cabergoline is a white powder that is soluble in ethyl alcohol, chloroform, and N, Ndimethylformamide (DMF). It is slightly soluble in 0.1N hydrochloric acid and insoluble in water. Cabgolin Tablets, for oral administration, contain 0.5 mg of cabergoline. The structure is shown below
Generic Forms and Brand names of Dostinex
Cabgolin Tablets manufactured by Sun Pharmaceuticals Ltd., India is an effective treatment for disorders associated with high prolactin levels. Dostinex which has the active ingredient cabergoline is also sold as Cabaser and under various other brand names.
Cabgolin Tablets (Generic Dostinex) - Preparations
Cabgolin Tablets is available as tablets of 0.5 mg.
Cabgolin Tablets (Generic Dostinex) - Storage Requirements
Cabgolin Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.
Cabgolin Tablets(Generic Dostinex) - Uses
Cabergoline in the form of Cabgolin Tablets is used for the treatment of hyperprolactinemic disorders, either idiopathic or due to pituitary adenomas. Cabergoline is also used as an adjunctive therapy of prolactin-producing pituitary gland tumors.
Cabgolin Tablets (Generic Dostinex) - Dosage
The recommended starting dosage of Cabgolin Tablets is 0.25 mg twice a week. Dosage may be increased by 0.25 mg twice weekly up to a dosage of 1 mg twice a week according to the patient’s serum prolactin level. Before sarting treatment with Cabgolim , cardiovascular evaluation should be performed and echocardiography should be considered to assess for valvular disease.
Dosage increases should not occur more frequently than every 4 weeks, so that the doctor can assess the patient’s response to each dosage level. If the patient does not respond adequately, and no additional benefit is observed with higher doses of Cabgolin, the lowest dose that achieved maximal response should be used.
Cabgolin Tablets (Generic Dostinex) - Contraindications
Cabgolin Tablets are contraindicated in patients with:
Uncontrolled hypertension or known hypersensitivity to ergot derivatives.
Hypersensitivity to Cabergoline or any inactive conponent of the medication.
History of cardiac valvular disorders, as suggested by anatomical evidence of valvulopathy of any valve, determined by pre-treatment evaluation including echocardiographic demonstration of valve leaflet thickening, valve restriction, or mixed valve restriction-stenosis.
History of pulmonary, pericardial, or retroperitoneal fibrotic disorders.
Cabgolin Tablets (Generic Dostinex) - Interactions
Cabgolin Tablets (Cabergoline) should not be administered concurrently with D2antagonists, such as phenothiazines, butyrophenones, thioxanthenes, or metoclopramide.
Side Effects Of Cabgolin Tablets (Generic Dostinex)
The most common side effects of Cabgolin Tablets are Nausea, Constipation, Abdominal pain, Dyspepsia, Vomiting, Headache, Dizziness, Paresthesia, Vertigo, Asthenia, Fatigue, Hot flashes, Somnolence, Depression, Nervousness, Postural hypotension, Breast pain, Dysmenorrhea and abnormal vision.
