Syndopa ( Generic Sinemet) - Active Ingredient And Chemical structure
Syndopa ( Generic Sinemet) is a combination of carbidopa and levodopa for the treatment of Parkinson's disease and syndrome.The active ingredient contained in Syndopa are Carbidopa and Levodopa. Carbidopa is is a white, crystalline compound which is slightly soluble in water. Levodopa which is a white crystalline compound is an aromatic amino acid, that is also slightly soluble in water. The structures are shown below
Structure Of Carbidopa
Structure Of Levodopa
Syndopa Tablets ( Generic Sinemet) - Uses
Generic Sinemet in the form of Syndopa Tablets is used to treat the symptoms of idiopathic Parkinson's disease (paralysis agitans), post-encephalitic parkinsonism, and symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication and/or manganese intoxication. Syndopa is indicated in these conditions to permit the administration of lower doses of levodopa with reduced nausea and vomiting, with more rapid dosage titration, with a somewhat smoother response, and with supplemental pyridoxine (vitamin B6).
Syndopa Tablets ( Generic Sinemet) - Contraindications
Nonselective monoamine oxidase (MAO) inhibitors are contraindicated for use with Syndopa Tablets . They (MAO inhibitors) must be discontinued at least two weeks prior to initiating therapy with Syndopa.Syndopa is contraindicated in patients with known hypersensitivity to any component of this drug, and in patients with narrow-angle glaucoma.
Because levodopa may activate a malignant melanoma, Syndopa should not be used in patients with suspicious, undiagnosed skin lesions or a history of melanoma.
Generic Forms and Brand names of Sinemet (combination of Carbidopa and Levodopa)
Syndopa manufactured by SUN Pharmaceuticals , India is an effective treatment for the symptoms of idiopathic Parkinson's disease (paralysis agitans), post-encephalitic parkinsonism, and symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication and/or manganese intoxication. Sinemet which has the active ingredients Carbidopa and Levodopa is also sold as Stalevo, Parcopa, Atamet and under various other brand names.
Syndopa Tablets ( Generic Sinemet) - Preparations
Syndopa Tablets are available in tablets which are a combination of Levodopa 100 mg & Carbidopa 10 mg, Levodopa 100 mg & Carbidopa 25 mg, Levodopa 200 mg & Carbidopa 50 mg and Levodopa 250 mg & Carbidopa 25 mg.
Syndopa Tablets ( Generic Sinemet) - Storage Requirements
Syndopa Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.
Syndopa Tablets ( Generic Sinemet) - Dosage
The optimum daily dosage of Syndopa Tablets must be determined by careful titration in each patient. Syndopa tablets are available in a 1:4 ratio of carbidopa to levodopa (Syndopa 25-100) as well as 1:10 ratio (Syndopa 25-250 and Syndopa 10-100).
Dosage is best initiated with one tablet of Syndopa 25-100 three times a day. This dosage schedule provides 75 mg of carbidopa per day. Dosage may be increased by one tablet every day or every other day, as necessary, until a dosage of eight tablets of Syndopa 25-100 a day is reached. If Syndopa 10-100 is used, dosage may be initiated with one tablet three or four times a day. Dosage may be increased by one tablet every day or every other day until a total of eight tablets (2 tablets, four times a day) is reached.
Syndopa Side Effects
The most common side effects of Syndopa Tablets ( Generic Sinemet) include dyskinesias, such as choreiform, dystonic, and other involuntary movements and nausea. Less common side effects that may occur during Syndopa Therapy are:
Body as a Whole: chest pain, asthenia.
Cardiovascular: cardiac irregularities, hypotension, orthostatic effects including orthostatic hypotension, hypertension, syncope, phlebitis, palpitation.
Gastrointestinal: dark saliva, gastrointestinal bleeding, development of duodenal ulcer, anorexia, vomiting, diarrhea, constipation, dyspepsia, dry mouth, taste alterations.
Hematologic: agranulocytosis, hemolytic and non-hemolytic anemia, thrombocytopenia, leukopenia.
Hypersensitivity: angioedema, urticaria, pruritus, Henoch-Schonlein purpura, bullous lesions (including pemphigus-like reactions).
Musculoskeletal: back pain, shoulder pain, muscle cramps.
Nervous System/Psychiatric: psychotic episodes including delusions, hallucinations, and paranoid ideation, neuroleptic malignant syndrome , bradykinetic episodes ("on-off" phenomenon), confusion, agitation, dizziness, somnolence, dream abnormalities including nightmares, insomnia, paresthesia, headache, depression with or without development of suicidal tendencies, dementia, pathological gambling, increased libido including hypersexuality, impulse control symptoms.
Respiratory: dyspnea, upper respiratory infection.
Skin: rash, increased sweating, alopecia, dark sweat.
Urogenital: urinary tract infection, urinary frequency, dark urine.
