Neotrexate Tablets (Generic Rheumatrex) - Active Ingredient And Chemical structure
The active ingredient contained in Neotrexate Tablets is Methotrexate. Neotrexate is an antimetabolite used in the treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis. The structure is shown below
Neotrexate Tablets (Generic Rheumatrex) - Uses
Methotrexate in the form of Neotrexate Tablets is used to treat cancer, autoimmune diseases, ectopic pregnancy, Eczema, Lymphoma and Trophoblastic Disease.
Generic Forms and Brand names of Rheumatrex
Neotrexate Tablets manufactured by GlaxoSmithKline, India is an effective treatment for neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis. Rheumatrex which has the active ingredient Methotrexate is also sold as Trexall, MTX, Amethopterin, Generic Methotrexate and under various other brand names.
Neotrexate Tablets (Generic Rheumatrex) - Preparations
Neotrexate (Methotrexate) is available as tablets of 2.5 mg.
Neotrexate Tablets (Generic Rheumatrex) - Storage Requirements
Neotrexate Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.
Neotrexate Tablets (Generic Rheumatrex)- Dosage
Choriocarcinoma and similar trophoblastic diseases:
Neotrexate Tablets (Methotrexate) is administered orally in doses of 15 to 30 mg daily for a five-day course. Such courses are usually repeated for 3 to 5 times as required, with rest periods of one or more weeks interposed between courses, until any manifesting toxic symptoms subside.
Psoriasis, Rheumatoid Arthritis, and Juvenile Rheumatoid Arthritis
The Recommended Starting Dosage schedules for Neotrexate Tablets (Generic Rheumatrex) to treat Adult Rheumatoid Arthritisis is
1. Single oral doses of 7.5 mg once weekly.
2. Divided oral dosages of 2.5 mg at 12 hour intervals for 3 doses given as a course once weekly.
The Recommended Starting Dosage schedules for Polyarticular-Course Juvenile Rheumatoid Arthritis:
The recommended starting dose is 10 mg/m2 given once weekly.
Neotrexate Tablets (Generic RMethotrexate) - Contraindications
Neotrexate Tablets (Methotrexate) is contraindicated in pregnant women with psoriasis or rheumatoid arthritis and should be used in the treatment of neoplastic diseases only when the potential benefit outweighs the risk to the fetus.
Pregnancy should be avoided if either partner is receiving methotrexate; during and for a minimum of three months after therapy for male patients, and during and for at least one ovulatory cycle after therapy for female patients. Patients with psoriasis or rheumatoid arthritis with alcoholism, alcoholic liver disease or other chronic liver disease should not receive methotrexate. Patients with psoriasis or rheumatoid arthritis who have overt or laboratory evidence of immunodeficiency syndromes should not receive methotrexate.
Patients with psoriasis or rheumatoid arthritis who have preexisting blood dyscrasias, such as bone marrow hypoplasia, leukopenia, thrombocytopenia or significant anemia, should not receive methotrexate.
Since Neotrexate has the potential for serious adverse reactions from methotrexate in breast fed infants, it is contraindicated in nursing mothers.
Patients with a known hypersensitivity to methotrexate or any inactive ingredient present in Neotrexate should not be administered the drug.
Side Effects Of Neotrexate Tablets (Generic Rheumatrex)
The most frequently occurring side effects of Neotrexate Tablets include ulcerative stomatitis, leukopenia, nausea, and abdominal distress. Other frequently reported side effects are malaise, undue fatigue, chills and fever, dizziness and decreased resistance to infection.
