Neotrexate Tablets | Generic Rheumatrex | Methotrexate | Dosage | Uses | Side effects

Neotrexate Tablets (Generic Rheumatrex) - Active Ingredient And Chemical structure

The active ingredient contained in Neotrexate Tablets is Methotrexate. Neotrexate is an antimetabolite used in the treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis. The structure is shown below

Neotrexate Tablets (Generic Rheumatrex) - Uses

Methotrexate in the form of Neotrexate Tablets is used to treat cancer, autoimmune diseases, ectopic pregnancy, Eczema, Lymphoma and Trophoblastic Disease.

Generic Forms and Brand names of Rheumatrex

Neotrexate Tablets manufactured by GlaxoSmithKline, India is an effective treatment for neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis. Rheumatrex which has the active ingredient Methotrexate is also sold as Trexall, MTX, Amethopterin, Generic Methotrexate and under various other brand names.

Neotrexate Tablets (Generic Rheumatrex) - Preparations

Neotrexate (Methotrexate) is available as tablets of 2.5 mg.

Neotrexate Tablets (Generic Rheumatrex) - Storage Requirements

Neotrexate Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.

Neotrexate Tablets (Generic Rheumatrex)- Dosage

Choriocarcinoma and similar trophoblastic diseases:
Neotrexate Tablets (Methotrexate) is administered orally in doses of 15 to 30 mg daily for a five-day course. Such courses are usually repeated for 3 to 5 times as required, with rest periods of one or more weeks interposed between courses, until any manifesting toxic symptoms subside.
Psoriasis, Rheumatoid Arthritis, and Juvenile Rheumatoid Arthritis
The Recommended Starting Dosage schedules for Neotrexate Tablets (Generic Rheumatrex) to treat Adult Rheumatoid Arthritisis is
1. Single oral doses of 7.5 mg once weekly.
2. Divided oral dosages of 2.5 mg at 12 hour intervals for 3 doses given as a course once weekly.
The Recommended Starting Dosage schedules for Polyarticular-Course Juvenile Rheumatoid Arthritis:
The recommended starting dose is 10 mg/m2 given once weekly.

Neotrexate Tablets (Generic RMethotrexate) - Contraindications

Neotrexate Tablets (Methotrexate) is contraindicated in pregnant women with psoriasis or rheumatoid arthritis and should be used in the treatment of neoplastic diseases only when the potential benefit outweighs the risk to the fetus.
Pregnancy should be avoided if either partner is receiving methotrexate; during and for a minimum of three months after therapy for male patients, and during and for at least one ovulatory cycle after therapy for female patients. Patients with psoriasis or rheumatoid arthritis with alcoholism, alcoholic liver disease or other chronic liver disease should not receive methotrexate. Patients with psoriasis or rheumatoid arthritis who have overt or laboratory evidence of immunodeficiency syndromes should not receive methotrexate.
Patients with psoriasis or rheumatoid arthritis who have preexisting blood dyscrasias, such as bone marrow hypoplasia, leukopenia, thrombocytopenia or significant anemia, should not receive methotrexate.
Since Neotrexate has the potential for serious adverse reactions from methotrexate in breast fed infants, it is contraindicated in nursing mothers.
Patients with a known hypersensitivity to methotrexate or any inactive ingredient present in Neotrexate should not be administered the drug.

Side Effects Of Neotrexate Tablets (Generic Rheumatrex)

The most frequently occurring side effects of Neotrexate Tablets include ulcerative stomatitis, leukopenia, nausea, and abdominal distress. Other frequently reported side effects are malaise, undue fatigue, chills and fever, dizziness and decreased resistance to infection.

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Fertomid Tablets | Generic Clomid | Clomiphene Citrate | Dosage | Uses | Side effects

Fertomid Tablets (Generic Clomid) - Active Ingredient And Chemical structure

The active ingredient contained in Fertomid Tablets is Clomiphene Citrate. Clomiphene citrate is a white to pale yellow crystalline powder which is essentially odorless. It is freely soluble in methanol; soluble in ethanol; slightly soluble in acetone, water, and chloroform. The structure is shown below

Generic Forms and Brand names of Clomid (Clomiphene Citrate)

Fertomid Tablets manufactured by Cipla Ltd., India is an effective treatment for patients with persistent ovulatory dysfunction. Clomid which has the active ingredient Clomiphene Citrate is also sold as Serophene, Milophene, Clomifert and under various other brand names.

Clomiphene Citrate - Uses

Clomiphene Citrate in the form of Fertomid Tablets is used for induction of ovulation in patients with persistent ovulatory dysfunction who desire pregnancy. Fertomid can be used to make an irregularly ovulating woman ovulate regularly.
Fertomid is useful in the treatment of oligomenorrhoea, dysfunctional uterine bleeding, amenorrhoea, post pill menorrhoea, Stein Leventhal syndrome (polycystic ovarian diseases), and Chiari Frommel syndrome.

Fertomid Tablets - Preparations

Fertomid (Generic Clomid) is available as tablets of 25 mg and 50 mg.

Fertomid Tablets (Clomiphene Citrate) - Storage Requirements

Fertomid Tablets are to be stored at room temperature (15°C to 30°C). Store Clomiphene away from heat, moisture, and light.

Contraindications Of Fertomid Tablets

Fertomid Tablets (Generic Clomid) are contraindicated in patients with a known hypersensitivity or allergy to clomiphene citrate or to any of its inactive ingredients.

Fertomid Tablets - Dosage

For the treatment of Female infertility One tablet of Fertomid 50 mg is to be administered daily for five days starting on the 5th day of the menstrual cycle. If ovulation does not appear to have occurred, a second course of two tablets of Fertomid 50 mg daily (in a single dose) for five days should be administered starting from the fifth day of the next cycle.

Side Effects Of Fertomid Tablets

The most common side effects of Fertomid Tablets (Clomiphene Citrate) are Ovarian Enlargement, Vasomotor Flushes, Abdominal-Pelvic Discomfort/Distention/Bloating, Nausea and Vomiting, Breast Discomfort, Blurred vision, lights, floaters, waves, unspecified visual complaints, photophobia, diplopia, scotomata, phosphenes, Headache, Abnormal Uterine Bleeding, Intermenstrual spotting, menorrhagia. Less common side effects that may occur are Acute abdomen, appetite increase, constipation, dermatitis or rash, depression, diarrhoea, dizziness, fatigue, hair loss/dry hair, increased urinary frequency/volume, insomnia, light-headedness, nervous tension, vaginal dryness, vertigo, weight gain/loss.

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Ciplox Tablets | Generic Cipro | Ciprofloxacin Hydrochloride | Dosage | Uses | Side effects

Ciplox Tablets (Generic Cipro) - Active Ingredient And Chemical structure

Ciplox (Generic Cipro) is a synthetic broad spectrum antimicrobial agents for oral administration. It is a faintly yellowish to light yellow crystalline substance with a molecular weight of 385.8. The active ingredient contained in Ciplox Tablets is Ciprofloxacin Hydrochloride. The structure is shown below

Generic Forms and Brand names of Cipro (Ciprofloxacin Hydrochloride)

Ciplox manufactured by Cipla Ltd., India is an effective treatment of certain infections caused by susceptible bacteria. Cipro which has the active ingredient Ciprofloxacin Hydrochloride is also sold as Ciloxan, Proquin Baycip, Ciloxan, Ciflox, Cipro XL, Ciproxin, Prociflor, Proquin and under various other brand names.

Generic Cipro (Ciprofloxacin Hydrochloride) - Uses

Ciprofloxacin Hydrochloride in the form of Ciplox Tablets is used to treat the below mentioned indications in Adult Patients:
Urinary Tract Infections caused by Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcescens, Proteus mirabilis, Providencia rettgeri, Morganella morganii, Citrobacter diversus, Citrobacter freundii, Pseudomonas aeruginosa, methicillin-susceptible Staphylococcus epidermidis, Staphylococcus saprophyticus, or Enterococcus faecalis. Acute Uncomplicated Cystitis in females caused by Escherichia coli or Staphylococcus saprophyticus.
Chronic Bacterial Prostatitis caused by Escherichia coli or Proteus mirabilis.
Lower Respiratory Tract Infections caused by Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Proteus mirabilis, Pseudomonas aeruginosa, Haemophilus influenzae, Haemophilus parainfluenzae, or penicillin-susceptible Streptococcus pneumoniae. Also, Moraxella catarrhalis for the treatment of acute exacerbations of chronic bronchitis.
Skin and Skin Structure Infections caused by Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Proteus mirabilis, Proteus vulgaris, Providencia stuartii, Morganella morganii, Citrobacter freundii, Pseudomonas aeruginosa, methicillin-susceptible Staphylococcus aureus, methicillin-susceptible Staphylococcus epidermidis, or Streptococcus pyogenes.
Bone and Joint Infections caused by Enterobacter cloacae, Serratia marcescens, or Pseudomonas aeruginosa.
Complicated Intra-Abdominal Infections (used in combination with metronidazole) caused by Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, or Bacteroides fragilis.
Infectious Diarrhea caused by Escherichia coli (enterotoxigenic strains), Campylobacter jejuni, Shigella boydii, Shigella dysenteriae, Shigella flexneri or Shigella sonnei when antibacterial therapy is indicated.
Typhoid Fever (Enteric Fever) caused by Salmonella typhi.
Uncomplicated cervical and urethral gonorrhea due to Neisseria gonorrhoeae.

Ciplox Tablets (Generic Cipro) - Preparations

Ciplox is available as tablets of 100 mg, 250 mg, 500 mg and 750 mg .

Ciplox Tablets - Storage Requirements

Ciplox Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.

Ciplox Tablets (Generic Cipro) - Dosage

Ciplox tablets should be swallowed whole with adequate amount of liquid.
Ciplox tablets can be taken with or without meals. Antacids should not be taken concomitantly or within two hours of dosing. Below are the recommended dosages for adults for the specific indications.
Respiratory tract, bone and joint infections
Mild/moderate 500 mg twice daily/or 1000 mg once daily
Severe/complicated 750 mg twice daily
Urinary tract infections
Acute uncomplicated 500 mg od for 3 days
Mild/moderate 250 mg twice daily / 500 mg once daily
Severe/complicated 500 mg twice daily/or 1000 mg once daily
Infectious diarrhoea
Mild/moderate/severe 500 mg twice daily/or 1000 mg once daily
Gonorrhoea 250 mg single dose
Non-gonococcal urethritis 750 mg twice daily
Chancroid 500 mg twice daily/1000 mg once daily
Other infections 500-750 mg twice daily
Chronic Bacterial prostatitis: 1000 mg o.d. for 28 days

Ciplox Tablets (Generic Cipro) - Contraindications

Ciplox is contraindicated in persons with a hypersensitivity to ciprofloxacin, any member of the quinolone class of antimicrobial agents, or any of the product inactive components.

Side Effects Of Ciplox Tablets (Generic Cipro)

Ciplox (Ciprofloxacin)is generally well tolerated. The most common side effects of are Diarrhoea, vomiting, abdominal pain, headache, restlessness and rash, have been reported. Other side effects which have been reported very rarely include myalgia, tendonitis/rupture, exacerbation of myasthenia gravis and increases in serum transaminase levels.

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