Lanzol Capsules (Generic Prevacid) - Active Ingredient And Chemical structure
The active ingredient contained in Lanzol Capsules is Lansoprazole. Lansoprazole is a white to brownish white odorless crystalline powder which melts with decomposition at approximately 166°C. Lansoprazole is freely soluble in dimethylformamide; soluble in methanol; sparingly soluble in ethanol; slightly soluble in ethyl acetate, dichloromethane and acetonitrile; very slightly soluble in ether; and practically insoluble in hexane and water. The structure is shown below
Generic Forms and Brand names of Generic Prevacid (Generic Prevacid)
Lanzol Capsule manufactured by Cipla Ltd., India is an effective treatment for used to treat and prevent Duodenal Ulcer and gastric ulcers, Gastroesophageal Reflux Disease (GERD),erosive esophagitis (damage to the esophagus from stomach acid), and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. Prevacid which has the active ingredient Lansoprazole is also sold as and under various other brand names.
Lanzol Capsules (Lansoprazole) - Uses
Lansoprazole in the form of Generic Prevacid Capsules (Lanzol Capsules) is used in the treatment of the below listed indications:
Short-Term Treatment of Active Duodenal Ulcer
Lanzol is indicated for short-term treatment (up to 4 weeks) for healing and symptom relief of active duodenal ulcer.
H. pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence
Lanzol in combination with amoxicillin plus clarithromycin as triple therapy is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or one-year history of a duodenal ulcer) to eradicate H. pylori. Eradication of H. pylori has been shown to reduce the risk of duodenal ulcer recurrence.
Lanzol in combination with amoxicillin as dual therapy is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or one-year history of a duodenal ulcer) who are either allergic or intolerant to clarithromycin or in whom resistance to clarithromycin is known or suspected.
Maintenance of Healed Duodenal Ulcers
Lanzol is indicated to maintain healing of duodenal ulcers. Controlled studies do not extend beyond 12 months.
Short-Term Treatment of Active Benign Gastric Ulcer
Lanzol is indicated for short-term treatment (up to 8 weeks) for healing and symptom relief of active benign gastric ulcer.
Healing of NSAID-Associated Gastric Ulcer
Lanzol is indicated for the treatment of NSAID-associated gastric ulcer in patients who continue NSAID use. Controlled studies did not extend beyond 8 weeks.
Risk Reduction of NSAID-Associated Gastric Ulcer
Lanzol is indicated for reducing the risk of NSAID-associated gastric ulcers in patients with a history of a documented gastric ulcer who require the use of an NSAID. Controlled studies did not extend beyond 12 weeks.
Gastroesophageal Reflux Disease (GERD)
Short-Term Treatment of Symptomatic GERD
Lanzol is indicated for the treatment of heartburn and other symptoms associated with GERD.
Short-Term Treatment of Erosive Esophagitis
Lanzol is indicated for short-term treatment (up to 8 weeks) for healing and symptom relief of all grades of erosive esophagitis. For patients who do not heal with Lanzol for 8 weeks (5-10%), it may be helpful to give an additional 8 weeks of treatment. If there is a recurrence of erosive esophagitis an additional 8-week course of Lanzol may be considered.
Maintenance of Healing of Erosive Esophagitis
Lanzol is indicated to maintain healing of erosive esophagitis. Controlled studies did not extend beyond 12 months.
Pathological Hypersecretory Conditions Including Zollinger-Ellison Syndrome
Lanzol is indicated for the long-term treatment of pathological hypersecretory conditions, including Zollinger-Ellison syndrome.
Lanzol Capsules (Generic Prevacid) - Preparations
Lanzol Capsules(Lansoprazole) is available as tablets of 15 mg and 30 mg .
Lanzol Capsules (Generic Prevacid) - Storage Requirements
Lanzol Capsules are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.
Lanzol Capsules - Dosage
The recommended dosage of Lanzol Capsules (Generic Prevacid) for variuous indications is given below:
| Indication | Recommended Adult Dose | Frequency | |
| Duodenal Ulcers | |||
| Short-Term Treatment | 15 mg | Once daily for 4 weeks | |
| Maintenance of Healed | 15 mg | Once daily | |
| H. pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence | |||
| Triple Therapy | |||
| Lanzol | 30 mg | Twice daily (q12h) for 10 or 14 days | |
| Amoxicillin | 1 gram | Twice daily (q12h) for 10 or 14 days | |
| Clarithromycin | 500 mg | Twice daily (q12h) for 10 or 14 days | |
| Dual Therapy: | |||
| Lanzol | 30 mg | Three times daily (q8h) for 14 days | |
| Amoxicillin | 1 gram | Three times daily (q8h) for 14 days | |
| Benign Gastric Ulcer | |||
| Short-Term Treatment | 30 mg | Once daily for up to 8 weeks | |
| NSAID-associated Gastric Ulcer | |||
| Healing | 30 mg | Once daily for 8 weeks | |
| Risk Reduction | 15 mg | Once daily for up to 12 weeks | |
| Gastroesophageal Reflux Disease (GERD) | |||
| Short-Term Treatment of Symptomatic GERD | 15 mg | Once daily for up to 8 weeks | |
| Short -Term Treatment of Erosive Esophagitis | 30 mg | Once daily for up to 8 weeks | |
Side Effects Of Lanzol
The most common side effects of are Abdominal Pain, Constipation, Diarrhea, Nausea. There are also some rarely occuring side effects that may occur in less than 1% of the patients undergoing Lanzol therapy.
