Wednesday, August 31, 2011

Penegra Tablets | Sildenafil Citrate | Dosage | Penegra Side effects

Penegra Tablets (Generic Viagra) - Active Ingredient And Chemical structure

Generic Viagra is an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). The active ingredient contained in Penegra tablets is Sildenafil citrate .Sildenafil citrate is a white to off-white crystalline powder with a solubility of 3.5 mg/mL in water. The structure is shown below

Sildenafil Citrate structure

Generic Forms and Brand names of Viagra (Sildenafil citrate)

Penegra manufactured by Zydus Cadila, India is an effective treatment for erectile dysfunction, also known as male impotence .Viagra which has the active ingredient Sildenafil citrate is also sold as Kamagra, Caverta, Silagra, Revatio and under various other brand names.

Penegra Tablets (Sildenafil citrate) - Uses

Sildenafil citrate in the form of Penegra Tablets is used to treat erectile dysfunction, also known as male impotence. Penegra is rapidly absorbed. Maximum observed plasma concentrations are reached within 30 to 120 minutes of oral dosing in the fasted state. When Penegra is taken with a high fat meal, the rate of absorption is reduced, with a mean delay in Time to reach maximum concentration of 60 minutes and a mean reduction in Concentration of 29%.

Penegra Tablets (Sildenafil citrate)- Preparations

Penegra is available as tablets of 25 mg, 50 mg and 100 mg . Each tablet of penegra (sildenafil citrate) is equivalent to 25 mg, 50 mg and 100 mg of sildenafil respectively for oral administration.

Penegra Tablets (Sildenafil citrate) - Storage Requirements

Penegra Tablets are to be stored at room temperature (25°C to 30°C). Store away from heat, moisture, and light.

Penegra Tablets - Dosage

For most patients, the recommended dose of Penegra is 50 mg taken, as needed, approximately 1 hour before sexual activity. Penegra may however be taken anywhere from 4 hours to half an hour before sexual activity. Based on effectiveness and toleration, the dose may be increased to a maximum of 100 mg or decreased to 25 mg. The maximum recommended dosing frequency is once a day.

Penegra Tablets (Sildenafil citrate) - Contraindications

Penegra is contraindicated in patients with a known hypersensitivity to Sildenafil citrate or to any inactive component of the tablet. Penegra (Sildenafil citrate) was shown to potentiate the hypotensive effects of nitrates, and its administration to patients who are using organic nitrates, either regularly and/or intermittently, in any form is therefore contraindicated. There is a potential for cardiac risk of sexual activity in patients with preexisting cardiovascular disease. Therefore, treatments for erectile dysfunction, including Sildenafil citrate, should not be generally used in men for whom sexual activity is inadvisable because of their underlying cardiovascular status.

Side Effects Of Penegra Tablets (Sildenafil citrate)

The most common side effects of Penegra are Headache, Flushing,Dyspepsia, Nasal Congestion, Urinary Tract Infection, Abnormal Vision (Mild and transient, predominantly color tinge to vision, but also increased sensitivity to light or blurred vision), Diarrhea, Dizziness and Rash.

Further Information

Prescribing Information