Thursday, September 29, 2011

Voveran Tablets | Generic Voltaren | Diclofenac Sodium | Dosage | Uses | Side effects

Voveran Tablets (Generic Voltaren) - Active Ingredient And Chemical structure

Voveran (diclofenac sodium enteric-coated tablets) is a benzene-acetic acid derivative. Voltaren is available as delayed-release (enteric-coated) tablets of 75 mg for oral administration.The active ingredient contained in Voveran is Diclofenac sodium . The structure is shown below

Structure Of Diclofenac Sodium


Generic Forms and Brand names of Voltaren (Diclofenac Sodium)

Voveran Tablets manufactured by Novartis, India is is used as an analgesic to treat pain, inflammatory disorders, and dysmenorrhea. Voltaren which has the active ingredient Diclofenac Sodium is also sold as oltaren delo, Voltarol Pain-eze, Voltaren Rapin, Voltaren T, Diclofenac T, Diclofenac-Asteria, Diclofenaco Normon, Morbidic, Voltaflam, Votrex, Cataflam, Abitren, Zipsor and under various other brand names.


Voveran Tablets - Preparations

Voveran is available as tablets of 50 mg and 100 mg .


Voveran Tablets - Storage Requirements


Voveran Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.


Voveran Tablets (Generic Voltaren) - Uses

Generic Voltaren in the form of Voveran Tablets is used to treat the following indications:
Relief of the signs and symptoms of osteoarthritis
Relief of the signs and symptoms of rheumatoid arthritis
For acute or long-term use in the relief of signs and symptoms of ankylosing spondylitis


Voveran Tablets - Contraindications

Voveran Tablets are contraindicated in patients with known hypersensitivity to diclofenac sodium. Voveran should not be given to patients who have experienced asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients. Voveran is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.


Voveran Tablets - Dosage

The individual patients dosage should be adjusted after observing the response to initial therapy with Voveran Tablets. For the relief of osteoarthritis, the recommended dosage is 100-150 mg/day in divided doses (50 mg twice a day or thrice a day, or 75 mg twice a day).
For the relief of rheumatoid arthritis, the recommended dosage is 150-200 mg/day in divided doses (50 mg thrice a day or four times a day, or 75 mg twice a day). For the relief of ankylosing spondylitis, the recommended dosage is 100-125 mg/day, administered as 25 mg four times a day, with an extra 25-mg dose at bedtime if necessary.


Side Effects Of Voveran Tablets (Generic Voltaren)

The most common side effects of Voveran Tablets (diclofenac sodium) or other NSAIDs occurring in approximately 1%-10% of patients are Gastrointestinal experiences including: abdominal pain, constipation, diarrhea, dyspepsia, flatulence, gross bleeding/perforation, heartburn, nausea, GI ulcers (gastric/duodenal) and vomiting.Abnormal renal function, anemia, dizziness, edema, elevated liver enzymes, headaches, increased bleeding time, pruritus, rashes and tinnitus. Less common side effects that may occur occasionally include:
Body as a Whole: fever, infection, sepsis
Cardiovascular System: congestive heart failure, hypertension, tachycardia, syncope
Digestive System: dry mouth, esophagitis, gastric/peptic ulcers, gastritis, gastrointestinal bleeding, glossitis, hematemesis, hepatitis, jaundice
Hemic and Lymphatic System: ecchymosis, eosinophilia, leukopenia, melena, purpura, rectal bleeding, stomatitis, thrombocytopenia
Metabolic and Nutritional: weight changes
Nervous System: anxiety, asthenia, confusion, depression, dream abnormalities, drowsiness, insomnia, malaise, nervousness, paresthesia, somnolence, tremors, vertigo
Respiratory System: asthma, dyspnea
Skin and Appendages: alopecia, photosensitivity, sweating increased
Special Senses: blurred vision
Urogenital System: cystitis, dysuria, hematuria, interstitial nephritis, oliguria/polyuria, proteinuria, renal failure
Other adverse reactions, which occur rarely are:
Body as a Whole: anaphylactic reactions, appetite changes, death
Cardiovascular System: arrhythmia, hypotension, myocardial infarction, palpitations, vasculitis
Digestive System: colitis, eructation, fulminant hepatitis with and without jaundice, liver failure, liver necrosis, pancreatitis
Hemic and Lymphatic System: agranulocytosis, hemolytic anemia, aplastic anemia, lymphadenopathy, pancytopenia
Metabolic and Nutritional: hyperglycemia
Nervous System: convulsions, coma, hallucinations, meningitis
Respiratory System: respiratory depression, pneumonia
Skin and Appendages: angioedema, toxic epidermal necrolysis, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, urticaria
Special Senses: conjunctivitis, hearing impairment


Symptoms And Treatment Of Voveran Tablets (Generic Voltaren) Overdose

Symptoms following acute Voveran Tablets or other NSAID overdoses are usually limited to lethargy, drowsiness, nausea,vomiting, and epigastric pain, which are generally reversible with supportive care. Gastrointestinal bleeding can occur. Hypertension, acute renal failure, respiratory depression and coma may occur, but are rare. Anaphylactoid reactions have been reported with therapeutic ingestion of NSAIDs, and may occur following an overdose.
Patients should be managed by symptomatic and supportive care following a NSAID overdose. There are no specific antidotes. Emesis and/or activated charcoal (60 to 100 g in adults, 1 to 2 g/kg in children) and/or osmotic cathartic may be indicated in patients seen within 4 hours of ingestion with symptoms or following a large overdose (5 to 10 times the usual dose).


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Prescribing Information

Tuesday, September 27, 2011

Crocin Tablets | Generic Paracetamol | Acetaminophen | Dosage | Uses | Side effects

Crocin Tablets (Generic Paracetamol) - Active Ingredient And Chemical structure

The active ingredient contained in Crocin Tablets is Paracetamol (Acetaminophen). Paracetamol (Acetaminophen) is a nonopiate, non-salicylate analgesic and antipyretic substance. Paracetamol is a white, odorless, crystalline powder, possessing a slightly bitter taste.The structure is shown below
Structure Of Paracetamol


Generic Forms and Brand names of Paracetamol

Crocin manufactured by GlaxoSmithKline, India is an effective treatment to reduce fever, for the relief of headaches as well as other minor aches and pains. Paracetamol (Acetaminophen) which has is also sold as Paracip, Fepanil, Panadol, Acetaminophen, Acamol, Acephen, Aceta, Actamin, Actimin, Anacin-3, Apacet, Atasol, Banesin, Ben-u-ron, Biogesic, Dafalgan, Dapa, Dolo, Datril, Efferalgan, DayQuil, Depon, Doliprane, Feverall, Fibi, Genapap, Genebs, Lekadol, LemSip, Liquiprin, Lupocet, Milidon, Neopap, Ny-Quil, Oraphen-PD, Ofirmev, Panado, Panadol, Panadrex, Panamax, Paracet, Parol, Panodil, Paratabs, Paralen, Phenaphen, Plicet, PyongSu Cetamol, Redutemp, Snaplets-FR, Suppap, Tactinal, Tachipirina, Tamen, Tapanol, Tempra, Uphamol, Valorin, Vitapap, Xcel and under various other brand names.


Crocin (Acetaminophen) - Uses

Acetaminophen is available as Generic Paracetamol Tablets is used for relief of persistent pain associated with osteoarthritis and muscle aches and pains such as backache. It is also used for reducing fever. Crocin also provides effective, temporary relief of pain and discomfort associated with headache, tension headache, period pain, toothache and pain after dental procedures, cold and flu.


Crocin Tablets (Paracetamol) - Preparations

Crocin (Acetaminophen) is available as tablets of 500 mg .


Crocin (Acetaminophen) - Storage Requirements

Crocin (Acetaminophen) are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.


Crocin (Paracetamol) - Dosage

The recommended dosage for adults and children over 12 years is Two tablets of 500 mg swallowed whole, every 6 to 8 hours (maximum of 6 tablets in any 24hours). The tablets must not be crushed.


Crocin (Paracetamol) - Contraindications

Crocin is contraindicated in persons that have a hypersensitivity to paracetamol or to any of the inactive ingredients. Crocin should be administered with caution to patients with hepatic or renal dysfunction. It is not recommended for children under 12 years of age.


Crocin (Paracetamol) - Overdose

Paracetamol overdose may cause hepatic failure. Immediate medical management is required in the event of overdose, even if symptoms of overdose are not present. Prompt treatment is essential even when there are no obvious symptoms.
In cases of over dosage, prompt administration of activated charcoal 50 g in 150 mL of water and 150 mL sorbitol 50% solution by mouth may reduce absorption. It is recommended that intravenous fluids such as Normal Saline be given concurrently. Gastric lavage is indicated if the patient is unwilling or unable to drink an activated charcoal/sorbitol mixture.


Side Effects Of Crocin (Paracetamol)

Reports of side effects are rare. Dyspepsia, nausea, allergic and haematological reactions have been reported but a causal relationship to the administration of paracetamol has been neither confirmed nor refuted.

Duprost Capsules | Generic Avodart | Dutasteride | Dosage | Uses | Side effects

Duprost Capsules (Generic Avodart) - Active Ingredient And Chemical structure

Dutasteride is a white to pale yellow powder with a melting point of 242°C to 250°C . It is soluble in ethanol (44 mg/mL), methanol (64 mg/mL), and polyethylene glycol 400 (3 mg/mL), but it is insoluble in water. Each Duprost Soft Gelatin Capsule, administered orally, contains 0.5 mg of dutasteride. The structure is shown below

Structure Of Dutasteride


Generic Forms and Brand names of Avodart (Dutasteride)

Duprost Capsules manufactured by Cipla Ltd. , India is an effective for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate. Avodart which has the active ingredient Dutasteride is also sold as Avidart, Avolve, Duagen, Dutagen, Dutas and under various other brand names.


Duprost Capsules (Generic Avodart) - Preparations

Duprost is available as Capsules of 0.5 mg .


Duprost Capsules (Generic Avodart) - Storage Requirements

Duprost Capsules are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.


Duprost Capsules (Generic Avodart) - Uses

Avodart in the form of Duprost Capsules a 5 alpha-reductase inhibitor indicated for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate to:
1) Improve symptoms
2) Reduce the risk of acute urinary retention, and
3) Reduce the risk of the need for BPH-related surgery.
Duprost Capsules in combination with the alpha adrenergic antagonist, tamsulosin, is indicated for the treatment of symptomatic BPH in men with an enlarged prostate.


Duprost Capsules (Generic Avodart) - Dosage

The recommended dosage for Duprost Monotherapy is 0.5 mg once daily. In Combination with tamsulosin: 0.5 mg once daily and tamsulosin 0.4 mg once daily. The capsules have to be swallowed whole. Capsules may be taken with or without food.


Duprost Capsules (Generic Avodart) - Contraindications

Duprost Capsules are contraindicated in the following cases:
Pregnancy and women of childbearing potential.
Pediatric patients.
Patients with previously demonstrated, clinically significant hypersensitivity (e.g., serious skin reactions, angioedema) to Duprost or other 5 alpha-reductase inhibitors.


Side Effects Of Duprost Capsules (Generic Avodart)

The most common side effects of are are impotence, decreased libido, ejaculation disorders, and breast disorders.


Further Information

Prescribing Information

Tuesday, September 20, 2011

Emeset Tablets | Generic Zofran | Ondansetron | Dosage | Uses | Side effects

Emeset Tablets (Generic Zofran) - Active Ingredient And Chemical structure

The active ingredient contained in Emeset Tablets is Ondansetron Hydrochloride Dihydrate. Ondansetron HCl Dihydrate is a white to off-white powder that is soluble in water and normal saline.The structure is shown below

Structure Of Ondansetron HCl


Generic Forms and Brand names of Zofran (Ondansetron HCl Dihydrate)

Emeset Tablets manufactured by Cipla Ltd., India is an effective treatment for prevention of nausea and vomiting associated with cancer chemotherapy and radiotherapy in patients. It is also used for the prevention of postoperative nausea and/or vomiting. Zofran which has the active ingredient Ondansetron Hydrochloride Dihydrate is also sold as Zuplenz, Emetron, Emodan, Ondemet, Setronax Ondavell and under various other brand names.


Emeset Tablets (Ondansetron HCl Dihydrate) - Preparations

Emeset Tablets is available as tablets of 4 mg and 8 mg . Each film coated tablet contains Ondansetron hydrochloride dihydrate Equivalent to 4 mg and 8 mg of Ondansetron respectively.


Emeset Tablets (Generic Zofran) - Uses

Zofran (Ondansetron HCl Dihydrate) in the form of Emeset Tablets is used to:
1.Prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy.
2.Prevention of nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer hemotherapy.
3.Prevention of nausea and vomiting associated with radiotherapy in patients receiving either total body irradiation, single high-dose fraction to the abdomen, or daily fractions to the abdomen.
4.Prevention of postoperative nausea and/or vomiting. As with other antiemetics, routine prophylaxis is not recommended for patients in whom there is little expectation that nausea and/or vomiting will occur postoperatively. In patients where nausea and/or vomiting must be avoided postoperatively, Emeset Tablets are recommended even where the incidence of postoperative nausea and/or vomiting is low.


Emeset Tablets (Generic Zofran) - Storage Requirements

Emeset Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.


Emeset Tablets - Dosage

The recommended dosage for the treatment of various indications is given below:
1. Prevention of Nausea and Vomiting Associated With Highly Emetogenic Cancer Chemotherapy.
The recommended adult oral dosage of Emeset is 24 mg given as three 8-mg tablets administered 30 minutes before the start of single-day highly emetogenic chemotherapy, including cisplatin >= 50 mg/m 2 .
2.Prevention of Nausea and Vomiting Associated With Moderately Emetogenic Cancer Chemotherapy
The recommended adult oral dosage is one 8-mg Emeset Tablet given twice a day. The first dose should be administered 30 minutes before the start of emetogenic chemotherapy, with a subsequent dose 8 hours after the first dose. One 8-mg EMESET Tablet should be administered twice a day (every 12 hours) for 1 to 2 days after completion of chemotherapy.
3.Prevention of Nausea and Vomiting Associated With Radiotherapy, Either Total Body Irradiation, or Single High-Dose Fraction or Daily Fractions to the Abdomen
The recommended oral dosage is one 8-mg Emeset Tablet given 3 times a day.
For total body irradiation , one 8-mg Emeset Tablet should be administered 1 to 2 hours before each fraction of radiotherapy administered each day.
4.Postoperative Nausea and Vomiting (PONV)
The recommended dosage is 16 mg given as two 8 mg Emeset Tablets 1 hour before induction of anesthesia.


Side Effects Of Emeset Tablets (Generic Zofran)

The most common side effects of Emeset Tablets are Headache, Malaise/fatigue,Constipation, Diarrhea and Dizziness.


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Prescribing Information

Friday, September 16, 2011

Omez Capsules | Generic Prilosec | Omeprazole | Dosage | Uses | Side effects

Omez Capsules (Omeprazole ) - Active Ingredient And Chemical structure

The active ingredient contained in Omez Capsules (Generic Prilosec) is Omeprazole. Omeprazole is a white to off-white crystalline powder that melts with decomposition at about 155°C. It is a weak base which is freely soluble in ethanol and methanol, and slightly soluble in acetone and isopropanol and very slightly soluble in water. The structure is shown below

Structure Of Omeprazole


Generic Forms and Brand names of Generic Prilosec (Omeprazole)

Omez Capsules manufactured by Dr. Reddy's Laboratories Ltd. , India is an effective treatment for dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GERD), laryngopharyngeal reflux (LPR) and pathological hypersecretory conditions (e.g. Zollinger-Ellison syndrome). Prilosec which has the active ingredient Omeprazole is also sold as Losec, Antra, Gastroloc, Mopral, Omepral, Zegerid, Segazole, Xelopes, Ulcozol and under various other brand names.


Omez Capsules (Generic Prilosec) - Uses

Omeprazole, a proton pump inhibitor in the form of Omez Capsules is used to treat duodenal ulcer in adults, gastric ulcer in adults, gastroesophageal reflux disease (GERD) in pediatric patients and adults, pathological hypersecretory conditions (eg, Zollinger-Ellison syndrome, multiple endocrine adenomas and systemic mastocytosis) in adults. It is also used for maintenance of healing of erosive esophagitis in pediatric patients and adults


Omez Capsules (Generic Prilosec) - Preparations

Omez is available as Capsules of 20 mg and 40 mg. Each delayed-release capsule contains either, 20 mg or 40 mg of omeprazole in the form of enteric-coated granules.



Omez Capsules (Generic Prilosec) - Storage Requirements

Omez Capsules are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.


Omez Capsules (Generic Prilosec) - Dosage

The recommended dosage of Omez capsules for various indications is given below:
Short-Term Treatment of Active Duodenal Ulcer:
The recommended adult dosage is 20 mg of Omez Once daily for 4 weeks. Some patients may require an additional 4 weeks
H. pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence
Triple Therapy:
Omez 20 mg, Amoxicillin 1000 mg, Clarithromycin 500 mg. Each drug twice daily for 10 days
Dual Therapy:
Omez 40 mg Once daily for 14 days. Clarithromycin 500 mg Three times daily for 14 days
Gastric Ulcer:
40 mg of Omez Once daily for 4 to 8 weeks
Gastroesophageal Reflux Disease (GERD)
20 mg of Omez Once daily for 4 to 8 weeks
Maintenance of Healing of Erosive Esophagitis
20 mg of Omez Once daily
Pathological Hypersecretory Conditions
60 mg (varies with individual patient) of Omez Once daily


Omez Capsules (Generic Prilosec) - Contraindications

Omez Capsules are contraindicated if the patient has a known hypersensitivity to Omeprazole or any inactive component of the medication.


Side Effects Of Omez Capsules (Generic Prilosec)

The most common side effects of Omez Capsules (Omeprazole )are Headache, abdominal pain, nausea, diarrhea, vomiting, and flatulence.


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Tegrital Tablets | Generic Tegretol | Carbamazepine | Dosage | Uses | Side effects

Tegrital Tablets (Generic Tegretol ) - Active Ingredient And Chemical structure

The active ingredient contained in Generic Tegretol is Carbamazepine. Carbamazepine is a white to off-white powder, which is practically insoluble in water and soluble in alcohol and in acetone.The structure is shown below

Structure Of Carbamazepine


Generic Tegretol (Carbamazepine) - Uses

Carbamazepine in the form of Generic Tegretol Tablets (Tegrital Tablets) is used to treat certain types of epileptic seizures and treats episodes of severe pain in the face originating from the trigeminal nerve (trigeminal neuralgia).


Generic Forms and Brand names of Tegretol (Carbamazepine)

Tegrital (Carbamazepine) manufactured by Novartis, India is an anticonvulsant and specific analgesic (treatment of the pain) for trigeminal neuralgia ( nerve disorder which causes intermittent severe pain in parts of the face). Tegretol which has the active ingredient Carbamazepine is also sold as Zeptol, Biston, Calepsin, Carbatrol, Epitol, Finlepsin and under various other brand names.


Tegrital Tablets (Generic Tegretol) - Preparations

Tegrital Tablets (Carbamazepine) is available as tablets of 200 mg for oral administration.


Tegrital Tablets (Generic Tegretol) - Storage Requirements

Tegrital Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.


Tegrital Tablets - Contraindications

Tegrital Tablets (Carbamazepine) should not be used in patients that have a history of previous bone marrow depression. It is also contraindicated in persons with a hypersensitivity to Carbamazepine or any other inactive ingredient of the medication, or known sensitivity to any of the tricyclic compounds, such as amitriptyline, desipramine, imipramine, protriptyline, nortriptyline, etc. It's concurrent use with monoamine oxidase inhibitors is not recommended. MAO inhibitors should be discontinued for a minimum of 14 days (or more, if possible) before administration of Generic Tegretol.


Tegrital Tablets - Dosage

The recommended dosage for Tegrital Tablets (Generic Tegretol) is given below:
Epilepsy :
Adults and children over 12 years of age: The Initial Dosage for Tegrital tablets is 200 mg twice a day. This may be increased at weekly intervals by adding up to 200 mg/day using a twice a day regimen of Tegretol until the optimal response is obtained.
Trigeminal Neuralgia:
Initial Adult Dosage: On the first day, 100 mg twice a day for Tegrital tablets for a total daily dose of 200 mg. This daily dose may be increased by up to 200 mg/day using increments of 100 mg every 12 hours for tablets only as required to achieve freedom from pain. Do not exceed 1200 mg daily.


Side Effects Of Tegrital Tablets (Carbamazepine)

The most common side effects of Tegrital Tablets particularly observed during the initial phases of therapy, are dizziness, drowsiness, unsteadiness, nausea, and vomiting. Inorder to minimize the possibility of such reactions, Tegrital therapy should be initiated at the lowest dosage recommended. Aplastic Anemia and Agranulocytosis have been reported in association with the use of Generic Tegretol. Less common side effects that may occur are:
Hemopoietic System: Aplastic anemia, agranulocytosis, pancytopenia, bone marrow depression, thrombocytopenia, leukopenia, leukocytosis, eosinophilia, acute intermittent porphyria.
Skin: Pruritic and erythematous rashes, urticaria, toxic epidermal necrolysis (Lyell's syndrome) , Stevens-Johnson syndrome, photosensitivity reactions, alterations in skin pigmentation, exfoliative dermatitis, erythema multiforme and nodosum, purpura, aggravation of disseminated lupus erythematosus, alopecia, and diaphoresis. In certain cases, discontinuation of therapy may be necessary.
Cardiovascular System: Congestive heart failure, edema, aggravation of hypertension, hypotension, syncope and collapse, aggravation of coronary artery disease, arrhythmias and AV block, thrombophlebitis, thromboembolism, and adenopathy or lymphadenopathy.
Liver: Abnormalities in liver function tests, cholestatic and hepatocellular jaundice, hepatitis; very rare cases of hepatic failure.
Pancreatic: Pancreatitis.
Respiratory System: Pulmonary hypersensitivity characterized by fever, dyspnea, pneumonitis, or pneumonia.
Genitourinary System: Urinary frequency, acute urinary retention, oliguria with elevated blood pressure, azotemia, renal failure, and impotence. Albuminuria, glycosuria, elevated BUN, and microscopic deposits in the urine have also been reported.
Nervous System: Dizziness, drowsiness, disturbances of coordination, confusion, headache, fatigue, blurred vision, visual hallucinations, transient diplopia, oculomotor disturbances, nystagmus, speech disturbances, abnormal involuntary movements, peripheral neuritis and paresthesias, depression with agitation, talkativeness, tinnitus, and hyperacusis.
Digestive System: Nausea, vomiting, gastric distress and abdominal pain, diarrhea, constipation, anorexia, and dryness of the mouth and pharynx, including glossitis and stomatitis.
Eyes: Scattered punctate cortical lens opacities, as well as conjunctivitis, have been reported. Although a direct causal relationship has not been established, many phenothiazines and related drugs have been shown to cause eye changes.
Musculoskeletal System: Aching joints and muscles, and leg cramps.
Metabolism: Fever and chills. Inappropriate antidiuretic hormone (ADH) secretion syndrome has been reported. Cases of frank water intoxication, with decreased serum sodium (hyponatremia) and confusion, have been reported in association with Tegretol use.


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Friday, September 9, 2011

Cabgolin Tablets | Generic Dostinex | Cabergoline | Dosage | Uses | Side effects

Cabgolin Tablets (Generic Dostinex) - Active Ingredient And Chemical structure

The active ingredient contained in Cabgolin Tablets is cabergoline, a dopamine receptor agonist. Cabergoline is a white powder that is soluble in ethyl alcohol, chloroform, and N, Ndimethylformamide (DMF). It is slightly soluble in 0.1N hydrochloric acid and insoluble in water. Cabgolin Tablets, for oral administration, contain 0.5 mg of cabergoline. The structure is shown below

Structure Of Cabergoline


Generic Forms and Brand names of Dostinex

Cabgolin Tablets manufactured by Sun Pharmaceuticals Ltd., India is an effective treatment for disorders associated with high prolactin levels. Dostinex which has the active ingredient cabergoline is also sold as Cabaser and under various other brand names.


Cabgolin Tablets (Generic Dostinex) - Preparations

Cabgolin Tablets is available as tablets of 0.5 mg.


Cabgolin Tablets (Generic Dostinex) - Storage Requirements

Cabgolin Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.


Cabgolin Tablets(Generic Dostinex) - Uses

Cabergoline in the form of Cabgolin Tablets is used for the treatment of hyperprolactinemic disorders, either idiopathic or due to pituitary adenomas. Cabergoline is also used as an adjunctive therapy of prolactin-producing pituitary gland tumors.


Cabgolin Tablets (Generic Dostinex) - Dosage

The recommended starting dosage of Cabgolin Tablets is 0.25 mg twice a week. Dosage may be increased by 0.25 mg twice weekly up to a dosage of 1 mg twice a week according to the patient’s serum prolactin level. Before sarting treatment with Cabgolim , cardiovascular evaluation should be performed and echocardiography should be considered to assess for valvular disease.
Dosage increases should not occur more frequently than every 4 weeks, so that the doctor can assess the patient’s response to each dosage level. If the patient does not respond adequately, and no additional benefit is observed with higher doses of Cabgolin, the lowest dose that achieved maximal response should be used.


Cabgolin Tablets (Generic Dostinex) - Contraindications

Cabgolin Tablets are contraindicated in patients with:
Uncontrolled hypertension or known hypersensitivity to ergot derivatives.
Hypersensitivity to Cabergoline or any inactive conponent of the medication.
History of cardiac valvular disorders, as suggested by anatomical evidence of valvulopathy of any valve, determined by pre-treatment evaluation including echocardiographic demonstration of valve leaflet thickening, valve restriction, or mixed valve restriction-stenosis.
History of pulmonary, pericardial, or retroperitoneal fibrotic disorders.


Cabgolin Tablets (Generic Dostinex) - Interactions

Cabgolin Tablets (Cabergoline) should not be administered concurrently with D2antagonists, such as phenothiazines, butyrophenones, thioxanthenes, or metoclopramide.


Side Effects Of Cabgolin Tablets (Generic Dostinex)

The most common side effects of Cabgolin Tablets are Nausea, Constipation, Abdominal pain, Dyspepsia, Vomiting, Headache, Dizziness, Paresthesia, Vertigo, Asthenia, Fatigue, Hot flashes, Somnolence, Depression, Nervousness, Postural hypotension, Breast pain, Dysmenorrhea and abnormal vision.


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Wednesday, September 7, 2011

Flonida Cream | Generic Carac | Fluorouracil | Dosage | Uses | Side effects

Flonida Cream (Generic Carac) - Active Ingredient And Chemical structure

Flonida (Fluorouracil) 1% and 5% Topical Cream is an antineoplastic/antimetabolite medication for dermatological use. The active ingredient contained in Flonida Cream is Fluorouracil. It is sparingly soluble in water and slightly soluble in alcohol. The structure is shown below

Structure Of Fluorouracil


Generic Forms and Brand names of Fluorouracil Cream (Generic Carac)

Flonida Cream manufactured by Shalaks, India is an effective treatment for for the topical treatment of multiple actinic (solar) keratoses. Carac Cream which has the active ingredient Fluorouracil is also sold as Fluorouracil Topical, Efudex, Fluoroplex and under various other brand names.


Flonida Cream - Preparations

Flonida Cream is available as 10 g tubes of 1% and 5% concentration.


Flonida Cream (Fluorouracil) - Uses

Fluorouracil in the form of Flonida Cream is used for the topical treatment of multiple actinic or solar keratoses of the face and anterior scalp. It is also used to treat other conditions such as basal cell carcinomas of the skin, Bowen's disease (a type of skin cancer), psoriasis, genital warts and porokeratosis (an unusual inherited skin condition causing dry patches on the arms and legs).


Flonida Cream - Storage Requirements

Flonida Cream is to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light. Keep out of the reach of children and pets.


Flonida Cream (Generic Carac) - Warninngs and Precautions

There exists the possibility for a delayed hypersensitivity reaction to Fluorouracil Cream. Hence patch testing for hypersensitivity may be inconclusive. The patient should avoid prolonged exposure to sunlight or any other forms of ultraviolet irradiation during treatment with Flonida Cream, as the intensity of the reaction may be increased.
Possibility exists of increased absorption through ulcerated or inflamed skin. Flonida Cream has to be applied with care near the eyes, nose, and mouth. Excessive reaction may occur in these areas due to irritation from accumulation of the medication. Flonida Cream is applied with the fingers, and the hands should be washed thouroughly soon afterwards. Patients should discontinue therapy with Fluorouracil Cream if symptoms of DPD enzyme deficiency develop. In rare cases, unexpected, systemic toxicity (e.g. stomatitis, diarrhea, neutropenia, and neurotoxicity) associated with parenteral administration of fluorouracil has been attributed to deficiency of DihydroPyrimidine Dehydrogenase "DPD" activity.


Flonida Cream (Fluorouracil) - Overdosage

Normally, overdosage of Flonida Cream will not cause acute problems. If Flonida Cream accidentally comes in contact with the eyes, flush the eyes with water or normal saline. If Flonida Cream is accidentally ingested, induce emesis and gastric lavage.


Flonida Cream (Generic Carac) - Dosage

Clean the affected area properly and wait 10 minutes before applying Flonida Cream (Generic Carac). Sufficient quantity of the medication has to be applied to cover the entire face or any other affected areas. Avoid contact with the eyes, eyelids, nostrils, and mouth. Apply the medication twice daily with fingertips and wash hands immediately afterwards. Normally a treatment period of two to six weeks is usually required. Increasing the frequency of application and a longer period of administration with Flonida Cream may be required on areas other than the head and neck.


Flonida Cream (Generic Carac) - Contraindications

Fluorouracil, the active ingredient in Flonida Cream may cause fetal harm when administered to a pregnant woman. Hence, Flonida Cream (Generic Carac) is contraindicated in women who are or may become pregnant. This medication should not be used by patients who are allergic to Fluorouracil or to any of the inactive components present in Flonida Cream.


Side Effects Of Flonida Cream (Fluorouracil Cream)

The most common side effects of are Pain, Pruritus, Burning, Irritation, Inflammation, allergic contact dermatitis and telangiectasia. Rarely, hyperpigmentation and scarring have also been reported.


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Monday, September 5, 2011

Crestor Tablets | Rosuvastatin Calcium | Dosage | Uses | Side effects

Crestor Tablets (Rosuvastatin Calcium) - Active Ingredient And Chemical structure

Crestor (Rosuvastatin Calcium) is a synthetic lipid-lowering agent for oral administration. The active ingredient contained in Crestor is Rosuvastatin Calcium. Rosuvastatin calcium is a white amorphous powder that is sparingly soluble in water and methanol, and slightly soluble in ethanol. The structure is shown below

Structure Of Rosuvastatin Calcium


Generic Forms and Brand names of Crestor Tablets (Rosuvastatin Calcium)

Crestor Tablets manufactured by Astra Zeneca, India is an effective treatment to slow down the production of cholesterol in the body and to prevent cardiovascular disease.


Crestor Tablets (Rosuvastatin Calcium) - Preparations

Crestor is available as tablets of 5 mg, 10 mg and 20 mg.


Crestor Tablets (Rosuvastatin Calcium) - Storage Requirements

Crestor Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.


Crestor Tablets (Rosuvastatin Calcium) - Uses

Rosuvastatin Calcium in the form of Crestor Tablets is used to treat the below mentioned indications:
Hyperlipidemia and Mixed Dyslipidemia
Crestor is indicated as adjunctive therapy to diet to reduce elevated Total-C, LDL-C, ApoB, nonHDL-C, and triglycerides and to increase HDL-C in adult patients with primary hyperlipidemia or mixed dyslipidemia.
Hypertriglyceridemia
Crestor is indicated as adjunctive therapy to diet for the treatment of adult patients with hypertriglyceridemia
Primary Dysbetalipoproteinemia (Type III Hyperlipoproteinemia)
Crestor is indicated as an adjunct to diet for the treatment of patients with primary dysbetalipoproteinemia (Type III Hyperlipoproteinemia).
Homozygous Familial Hypercholesterolemia
Crestor is indicated as adjunctive therapy to other lipid-lowering treatments (e.g., LDL apheresis) or alone if such treatments are unavailable to reduce LDL-C, Total-C, and ApoB in adult patients with homozygous familial hypercholesterolemia.
Slowing of the Progression of Atherosclerosis
Crestor is indicated as adjunctive therapy to diet to slow the progression of atherosclerosis in adult patients as part of a treatment strategy to lower Total-C and LDL-C to target levels.


Crestor Tablets (Rosuvastatin Calcium) - Dosage

The recommended dose range for Crestor is 5 to 40 mg orally once daily. Crestor can be administered as a single dose at any time of day, with or without food.
Hyperlipidemia, Mixed Dyslipidemia, Hypertriglyceridemia, Primary Dysbetalipoproteinemia (Type III Hyperlipoproteinemia) and Slowing of the Progression of Atherosclerosis
The recommended starting dose of Crestor is 10 mg once daily. For patients with marked hyperlipidemia (LDL-C > 190 mg/dL) and aggressive lipid targets, a 20 mg starting dose may be considered.
Homozygous Familial Hypercholesterolemia
The recommended starting dose of Crestor is 20 mg once daily.


Crestor Tablets (Rosuvastatin Calcium) - Contraindications

Crestor is contraindicated in patients with a known hypersensitivity to Rosuvastatin Calcium or any inactive component of this medication.


Side Effects Of Crestor Tablets (Rosuvastatin Calcium)

The most common side effects of are headache, myalgia, abdominal pain, asthenia and nausea. Serious side effects include Rhabdomyolysis with myoglobinuria, acute renal failure, myopathy and Liver enzyme abnormalities.


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Saturday, September 3, 2011

Distinon Tablets | Generic Mestinon | Pyridostigmine Bromide | Dosage | Uses | Side effects

Distinon Tablets (Pyridostigmine Bromide) - Active Ingredient And Chemical structure

Distinon Tablets (Generic Mestinon) is an orally active cholinesterase inhibitor. The active ingredient contained in Distinon Tablets is Pyridostigmine Bromide. The structure is shown below

Structure Of Pyridostigmine Bromide


Generic Forms and Brand names of Mestinon (Pyridostigmine Bromide)

Distinon manufactured by Samarth Pharma Pvt. Ltd. , India is an effective treatment for myasthenia gravis. Mestinon which has the active ingredient Pyridostigmine Bromide is also sold as Regonol and under various other brand names.


Pyridostigmine Bromide (Generic Mestinon) - Uses

Pyridostigmine Bromide in the form of Generic Mestinon Tablets is used to treat muscle weakness in people with myasthenia gravis as well as counter the effects of curariform drug toxicity.


Distinon Tablets (Pyridostigmine Bromide) - Preparations

Distinon Tablets (Generic Mestinon) is available as tablets of 60 mg .


Distinon Tablets (Pyridostigmine Bromide) - Storage Requirements

Distinon Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.


Distinon Tablets (Generic Mestinon) - Dosage

The size and frequency of dosage of Distinonmust be adjusted to the needs of the individual patient. The average dose of Distinon is ten 60 mg tablets daily, spaced to provide maximum relief when maximum strength is needed.


Distinon (Generic Mestinon) Tablets (Pyridostigmine Bromide) - Contraindications

Distinon is contraindicated in patients with a hypersensitivity to Pyridostigmine Bromide or any inactive ingredient present in the medication. Mestinon is contraindicated in mechanical intestinal or urinary obstruction, and particular caution should be used in its administration to patients with bronchial asthma.


Side Effects Of Distinon Tablets (Generic Mestinon)

The most common Muscarinic side effects of Generic Mestinon are nausea, vomiting, diarrhea, abdominal cramps, increased peristalsis, increased salivation, increased bronchial secretions, miosis and diaphoresis. Nicotinic side effects are comprised chiefly of muscle cramps, fasciculation and weakness.


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Friday, September 2, 2011

Nexpro Tablets | Generic Nexium | Esomeprazole | Dosage | Uses | Side effects

Nexpro Tablets (Generic Nexium) - Active Ingredient And Chemical structure

The active ingredient contained in Nexpro Tablets is Esomeprazole Magnesium, a compound that inhibits gastric acid secretion. Esomeprazole Magnesium is a white to slightly colored crystalline powder which is slightly soluble in water. The structure is shown below

Structure Of Esomeprazole


Generic Nexium (Esomeprazole Magnesium) - Uses

Generic Nexium (Esomeprazole Magnesium) in the form of Nexpro Tablets is used in the treatment of Gastroesophageal Reflux Disease (GERD), Risk Reduction of NSAID-Associated Gastric Ulcer, H. pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence, Pathological Hypersecretory Conditions Including Zollinger-Ellison Syndrome.


Generic Forms and Brand names of Nexium (Esomeprazole Magnesium)

Nexpro Tablets manufactured by Torrent Pharmaceuticals Ltd., India is an effective treatment for symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid. Nexium which has the active ingredient Esomeprazole Magnesium is also sold as Sompraz, Esopral, Lucen, Axagon, Nexiam or Zoleri and under various other brand names.


Nexpro Tablets (Generic Nexium) - Preparations

Nexpro Tablets (Esomeprazole Magnesium) are available as tablets of 20 mg and 40 mg .


Nexpro Tablets - Storage Requirements

Nexpro Tablets (Esomeprazole Magnesium) are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light. Keep away from children and pets.


Nexpro Tablets (Esomeprazole Magnesium) - Dosage

The recommended dosage of Nexpro tablets for various indications is given below:

Indication Dose Frequency
Gastroesophageal Reflux Disease (GERD)
Healing of Erosive Esophagitis20 mg or 40 mgOnce Daily for 4 to 8 Weeks
Maintenance of Healing of Erosive Esophagitis20 mg Once Daily
Symptomatic Gastroesophageal Reflux Disease20 mgOnce Daily for 4 Weeks
Risk Reduction of NSAID Associated Gastric Ulcer 20 mg or 40 mgOnce Daily for up to 6 months
H.pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence
Triple Therapy:
Nexpro40 mgOnce Daily for 10 Days
Amoxicillin1000 mgTwice Daily for 10 Days
Clarithromycin500 mgTwice Daily for 10 Days
Pathological Hypersecretory Conditions Including Zollinger-Ellison Syndrome40 mgTwice Daily

Nexpro Tablets (Generic Nexium) - Contraindications

Nexpro is contraindicated in patients with known hypersensitivity to any component of the formulation or to substituted benzimidazoles.


Side Effects Of Nexpro Tablets (Generic Nexium)

The most common side effects of are Headache, diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth.


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