Lametec Tablets | Generic Lamictal | Lamotrigine | Dosage | Uses | Side effects

Lametec Tablets (Generic Lamictal) - Active Ingredient And Chemical structure

The active ingredient contained in Lametec Tablets is Lamotrigine. Lamotrigine is a white to pale cream-colored powder and is very slightly soluble in water (0.17 mg/mL at 25°C) and slightly soluble in 0.1 M HCl. The structure is shown below

Generic Forms and Brand names of Lamictal

Lametec Tablets manufactured by Cipla Ltd., India is an effective treatment for Epilepsy adjunctive and mono therapy, generalized seizures of Lennox-Gastaut syndrome and Bipolar Disorder. Generic Lamictal which has the active ingredient Lamotrigine is also sold under various other brand names.

Lamictal Tablets (Lamotrigine) - Uses

Lamotrigine, an antiepileptic drug (AED) in the form of Lametec Tablets is used to treat the following indications:
Epilepsy-adjunctive therapy in patients 2 years of age or more:
partial seizures.
primary generalized tonic-clonic seizures.
generalized seizures of Lennox-Gastaut syndrome.

Epilepsy—monotherapy in patients 16 years of age or greater:
conversion to monotherapy in patients with partial seizures who are receiving treatment with carbamazepine, phenobarbital, phenytoin, primidone, or valproate as the single AED.

Bipolar Disorder in patients 18 years of age and above:
maintenance treatment of Bipolar I Disorder to delay the time to occurrence of mood episodes in patients treated for acute mood episodes with standard therapy.

Lametec Tablets (Generic Lamictal) - Preparations

Lametec is available as tablets of 25 mg, 50 mg and 100 mg .Each dispersible tablet contains Lamotrigine 25 mg, 50 mg and 100 mg respectively.

Lametec Tablets - Storage Requirements

Lametec Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.

Lametec Tablets (Lamotrigine) - Mechanism of Action

The exact ways by which lamotrigine (Lametec Tablets) exerts its anticonvulsant action are unknown. In animal models that were designed to detect anticonvulsant activity, lamotrigine was effective in preventing seizure spread in the maximum electroshock (MES) and pentylenetetrazol (scMet) tests, and prevented seizures in the visually and electrically evoked after-discharge (EEAD) tests for antiepileptic activity.

Lametec Tablets (Lamotrigine) - Dosage

The Dosage for Lametec Tablets is based on concomitant medications, indication, and the age of the patient. To avoid an increased risk of rash, the recommended initial dose and subsequent dose escalations should not be exceeded. Lametec (Lamotrigine) Tablets should be swallowed with water.

Monotherapy with Lametec in patients 16 years of age or more:

Lametec is to be titrated to the targeted dose of 50 mg/day while maintaining the dose of the enzyme-inducing antiepileptic drugs(EIAEDs) at a fixed level. The EIAEDs are then gradually withdrawn over a period of 4 weeks.Recommended maintenance dose of Lametec DT as monotherapy is 500 mg/day given in two divided doses.
Bipolar Disorder:
The recommended initial adult dosage of Lametec DT is 25 mg once daily for 2 weeks, followed by 50 mg once daily for 2 weeks.
The recommended adult (over 12 years) dosage for lametec (mg/day) is given below

	Weeks 1 & 2	Weeks 3 & 4	Usual Maintenance Dose
With enzyme-inducing antiepileptic drugs(EIAEDs) & No Valproic acid (VPA)	50mg/day (Once a day)	100mg/day (Two divided doses)	300mg to 500mg/day (Two divided doses). To achieve maintenence doses may be incresed by 100mg/day every 1-2 weeks
EIAEDs & Valproic acid (VPA)	25 mg every other day	25mg (Once a day)	100mg to 400mg/day (Two divided doses). To achieve maintenence doses may be incresed by 25 mg - 50mg/day every 1-2 weeks

As there exists a risk of rash the initial dose and subsequent dose escalation should not be exceeded.

The recommended dose escalation for lamotrigine (lametec) for children aged 2-12 years (total daily dose in mg/kg body weight/day) on combined drug therapy is given below.

	Weeks 1 & 2	Weeks 3 &	Usual Maintenance Dose
With AED regimen containing VPA	0.15mg/kg/day (1 or 2 divided doses)	0.3mg/kg/day (1 or 2 divided doses)	1mg - 5mg/kg/day (Maximum 200mg/day in One or Two divided doses)To achieve maintenence doses may be incresed by 0.5 - 1mg/kg/day every 1-2 weeks
Added to EIAEDs and wirhout VPA	0.6mg/kg/day (2 divided doses)	1.2mg/kg/day (2 divided doses)	5mg - 15mg/kg/day (Maximum 400mg/day in One or Two divided doses)To achieve maintenence doses may be incresed by 2 - 3mg/kg/day every 1-2 weeks

After initial 4 weeks of therapy, the daily dosage of Lametec DT may be doubled at weekly intervals until an effective maintenance dosage of 200 mg daily is reached. The daily dosages should not exceed 200 mg daily.

Lametec DT Tablets - Contraindications

Lametec DT Tablets are contraindicated in patients who have demonstrated hypersensitivity to Lamotrigine or any inactive ingredient present in the medicine.

Side Effects Of Lametec DT Tablets (Generic Lamictal or Lamotrigine)

The common adverse effects (incidence 10% or greater) of Lamotrigine (Lametec DT Tablets) in adult epilepsy clinical studies were dizziness, headache, diplopia, ataxia, nausea, blurred vision, somnolence, rhinitis, and rash.
Additional adverse reactions (incidence 10% or greater) reported in children in epilepsy clinical studies included vomiting, infection, fever, accidental injury, pharyngitis, abdominal pain, and tremor. Most common adverse effects with an incidence rate 5% or more in adult bipolar clinical studies were nausea, insomnia, somnolence, back pain, fatigue, rash, rhinitis, abdominal pain, and xerostomia.

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Chloromycetin Aplicaps | Chloramphenicol Eye Ointment | Dosage | Uses | Side effects

Chloromycetin Aplicaps (Chloramphenicol Eye Ointment) - Active Ingredient And Chemical structure

The active ingredient contained in Chloromycetin Aplicaps is Chloramphenicol. Chloramphenicol is a white to greyish-white or yellowish-white, fine crystalline powder or fine crystals, needles or elongated plates. It is soluble to the extent of 1 in 400 of water, 1 in 2.5 of alcohol, and 1 in 7 of propylene glycol; freely soluble in acetone and ethyl acetate; slightly soluble in ether. The structure is shown below

Chloromycetin Aplicaps (Chloramphenicol Eye Ointment) - Uses

Chloramphenicol Eye Ointment in the form of Chloromycetin is a topical antibiotic preparation for the treatment of bacterial conjunctivitis.

Generic Forms and Brand names of Chloramphenicol Eye Ointment

Chloromycetin Aplicaps manufactured by Pfizer Ltd., India is an effective treatment for Ocular bacterial infections caused by organisms susceptible to chloramphenicol.

Chloromycetin Aplicaps - Preparations

Chloromycetin is available as aplicaps of 250 mg. Each Aplicap contains 250 mg of chloramphenicol eye ointment I.P. (1%) in an oleaginous ointment base.

Chloromycetin Aplicaps (Chloramphenicol Eye Ointment) - Storage Requirements

Chloromycetin Aplicaps are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.

Chloromycetin Aplicaps (Chloramphenicol Eye Ointment) - Dosage

To use Chloramphenicol Eye Ointment , wipe the tip of the the aplicap with alcohol, cut the end with a clean instrument and compress the body to squeeze out the contents. Apply the Chloramphenicol Eye ointment, to the affected eye by placing in the lower conjunctival sac every 3 hours or more frequently if necessary. Continue administration day and night for the first 48 hours, at which time the frequency of application can be decreased. Treatment should be continued for at least 48 hours after the eye appears normal.

Chloromycetin Aplicaps (Chloramphenicol Eye Ointment) - Contraindications

Chloromycetin Aplicaps eye ointment is contraindicated in individuals with a history of hypersensitivity and/or toxic reaction to chloramphenicol or any inactive ingredient present in the medication.

Side Effects Of Chloromycetin Aplicaps (Chloramphenicol Eye Ointment)

Blood dyscrasias have been reported in association with the use of Chloromycetin Aplicaps. Chloramphenicol is absorbed systemically from the eye, and toxicity has been reported following chronic exposure. Dose-related toxicity following a single ocular exposure is unlikely.The most common side effects with Chloramphenicol Eye Ointment are Local irritation which includes subjective symptoms of itching or burning.
More Serious side effects such as angioneurotic oedema, anaphylaxis, urticaria, fever, vesicular and maculopapular dermatitis have been reported in patients sensitive to chloramphenicol. Discontinue promptly if any serious side effects occur.

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Nicotex Chewing Gum | Generic Nicorette | Dosage | Uses | Side effects

Nicotex Chewing Gum (Generic Nicorette) - Active Ingredient And Chemical structure

Nicotex Chewing Gum is designed to provide partial substitution for the nicotine in cigarette smoke, which is believed to be one of the principal factors in the prolonging the smoking habit. Nicotex Gum is intended to cushion the patients against the trauma of withdrawal. The active ingredient contained in is Nicotine Polacrilex . The structure is shown below

Nicotex Chewing Gum (Nicotine Gum) - Uses

Nicotine Gum in the form of Generic Nicorette Gum is used as an aid for for smoking cessation therapy. Nicotex Chewing Gum reduces withdrawal symptoms, including nicotine craving, associated with quitting smoking.

Generic Forms and Brand names of Nicotine Chewing Gum

Nicotex Chewing Gum manufactured by Cipla Ltd., India is an effective treatment aid in nicotine replacement therapy (NRT), a process which helps smokers quit smoking tobacco. Nicorette which has the active ingredient Nicotine Polacrilex is also sold as Nicoderm, Nicogum, Nicotex and Nicotinell.

Nicotex Chewing Gum - Preparations

Nicotex Gum is available as packs of 10 gum pieces. Each piece of Nicotex Chewing Gum contains either 2 mg or 4 mg of Nicotine polacrilex.

Nicotex Chewing Gum - Storage Requirements

Nicotex Chewing Gum is to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.

Nicotex Chewing Gum (Nicotine Gum)- Dosage

The dosing schedule is given below: Patients smoking 25 or more cigarettes a day, have to use 4 mg nicotine gum whereas patients that were smoking less than 25 cigarettes a day, should use 2 mg nicotine gum. Nicotex Chewing Gum has to be used as per the following 12-week schedule:
Weeks 1-6: One piece of gum every 1-2 hours
Weeks 7-9: One piece of gum every 2-4 hours
Weeks 10-12: One piece of gum every 4-8 hours. Do not use more than 24 pieces of Nicotex gum a day.

How To Use Nicotex Chewing Gum (Generic Nicorette) For Maximum Benefit

Each gum piece of gum has to be chewed very slowly several times.Stop chewing Nicotex Chewing Gum when you get a peppery taste or a slight tingling in the mouth. This usually happens after about 1 minute or 15 chews, but may vary from person to person. Shift the chewing gum to one corner or side of your mouth, and leave it there.
When the peppery taste or tingle is almost gone (in about a minute), again start chewing the gum piece slowly. Stop when the taste or tingle returns and shift the gum to a different place in your mouth every time. Repeat the chewing and shifting process of the gum till most of the nicotine is gone from the Nicotex Chewing Gum. This usually happens in about 30 minutes and the peppery taste or tingle will not return.

Nicotex Chewing Gum (Generic Nicorette) - Contraindications

Nicotex Chewing Gum is contraindicated in patients with a hypersensitivity to nicotine polacrilex or any other inactive ingredients present in the chewing gum. Nicotex Chewing Gum is also contraindicated in pregnancy because of well known adverse effect of nicotine on the fetus. Generic Nicorette is also contraindicated in breast feeding mothers, as nicotine is excreted in breast milk.

Side Effects Of Nicotex Chewing Gum (Generic Nicorette)

The most common side effects of Nicotex Chewing Gum, usually in the early days of treatment are apthous ulcers, throat irritation, excessive salivation and hiccups. These symptoms are usually more frequent and severe with the 4 mg gums than the 2 mg version.
Excessive weight gain is sometimes associated with abstention of smoking. Hence, a patient on Nicorette therapy has to be weighed at regular intervals, and if required suitable modifications in diet should be done.

Duovir-N Tablets | Dosage | Uses | Side effects

Duovir-N Tablets - Active Ingredient And Product Information

Duovir-N Tablets are a combination of three drugs namely zidovudine, lamivudine and Nevirapine that are commonly used in the management of the Human Immunodeficiency Virus (HIV) infection. Zidovudine and lamivudine belong to the nucleoside analogue class of antiretroviral drugs which act by terminating the growth of the DNA chain and inhibiting the reverse transcriptase (RT) of HIV. Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It acts by directly inhibiting Reverse Transcriptase.
The active ingredients contained in Duovir-N Tablets is zidovudine, lamivudine and Nevirapine.

Duovir-N Preparations

Duovir-N is available as tablets which have a combination of three drugs Lamivudine, Zidovudine and Nevirapine . Each film coated tablet contains Lamivudine 150 mg, Zidovudine 300 mg BP and Nevirapine 200 mg

Duovir-N - Storage Requirements

Duovir-N are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.

Duovir-N - Uses

Duovir-N Tablets are used for the treatment of HIV infection, once patients have been stabilized on the maintenance regimen of nevirapine 200 mg twice a day, and have demonstrated adequate tolerability to nevirapine.

Duovir-N - Dosage

The recommended adult dosage of Duovir-N is One tablet twice daily.

Duovir-N - Contraindications

Duovir-N Tablets are contraindicated in patients with previously demonstrated clinically significant hypersensitivity (eg, anaphylaxis, Stevens-Johnson syndrome) to zidovudine, lamivudine and Nevirapine or any inactive components of the product. It is also contraindicated in patients with moderate or severe (Childs Pugh Class B or C, respectively) hepatic impairment.

Duovir-N - Warnings and Precautions

Hepatotoxicity and Hepatic Impairment
Severe, life threatening and, in some cases, fatal hepatotoxicity, including fulminant and cholestatic hepatitis, hepatic necrosis and hepatic failure, have been reported in patients treated with nevirapine.
Skin Reactions
Severe and life-threatening skin reactions, including fatal cases, have been reported with nevirapine treatment, occurring most frequently during the first 6 weeks of therapy. These have included cases of Stevens-Johnson syndrome, toxic epidermal necrolysis and hypersensitivity reactions characterized by rash, constitutional findings and organ dysfunction, including hepatic failure.
Resistance
Nevirapine must not be used as a single agent to treat HIV or added on as a sole agent to a failing regimen. As with all other NNRTIs, resistant virus emerges rapidly when nevirapine is administered as monotherapy.
Immune Reconstitution Syndrome
Immune reconstitution syndrome has been reported in patients treated with combination antiretroviral therapy, including lamivudine, zidovudine and nevirapine. During the initial phase of combination antiretroviral treatment, patients whose immune system responds may develop an inflammatory response to indolent or residual opportunistic infections.

Side Effects Of Duovir-N

The most common side effects of Duovir-N are
Body as a Whole
Headache ,Malaise and fatigue, Fever or chills
Digestive
Nausea, Diarrhea, Nausea and vomiting, Anorexia and/or decreased appetite, Abdominal pain, Abdominal cramps, Dyspepsia
Nervous System
Neuropathy, Insomnia and other sleep disorders, Dizziness, Depressive disorders
Respiratory
Nasal signs and symptoms, Cough
Skin
Skin rashes
Musculoskeletal
Musculoskeletal pain, Myalgia, Arthralgia

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Cobese Capsules | Generic Xenical | Dosage | Uses | Side effects

Cobese Capsules (Generic Xenical) - Active Ingredient And Chemical structure

The active ingredient contained in Cobese Tablets is Orlistat. Orlistat is a white to off-white crystalline powder. Orlistat is practically insoluble in water, freely soluble in chloroform, and very soluble in methanol and ethanol. Orlistat is a lipase inhibitor which is used for obesity management. It acts by inhibiting the absorption of dietary fats. The structure is shown below

Cobese Capsules (Generic Xenical) - Uses

Generic Xenical in the form of Cobese Capsules is used for obesity management including weight loss and weight maintenance when used in conjunction with a reduced-calorie diet.
Generic Xenical is also used to reduce the risk for regaining weight after prior weight loss. Generic Xenical is indicated for obese patients with an initial body mass index (BMI) of greater than or equal to 30 kg/m2 or greater than or equal to 27 kg/m2 in the presence of other risk factors (eg, hypertension, diabetes, dyslipidemia).

Generic Forms and Brand names of Xenical

Cobese manufactured by Rambaxy Laboratories Ltd., India is an effective treatment for persons suffering from obesity, in its ability to manage adiposis in adult and adolescent patients. Xenical which has the active ingredient Orlistat is also sold as Alli, Orlimac, Vyfat, Orlistat and under various other brand names.

Cobese Capsules (Generic Xenical) - Preparations

Cobese is available as Capsules of 120 mg. Each capsule of Generic Xenical contains a pellet formulation consisting of 120 mg of the active ingredient, orlistat, as well as the inactive ingredients.

Cobese Capsules (Generic Xenical) - Storage Requirements

Cobese Capsules are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.

Cobese Capsules (Generic Xenical) - Dosage

The recommended dose of Generic Xenical is one 120 mg capsule three times a day with each main meal containing fat to be taken during or up to 1 hour after the meal. In case a meal is occasionally missed or contains no fat, the dose of Cobese can be omitted.

Cobese Capsules (Generic Xenical) - Contraindications

Cobese Capsules (Generic Xenical) is contraindicated in patients with chronic malabsorption syndrome or cholestasis, and in patients with known hypersensitivity to Orlistat or to any inactive component of this product.

Generic Xenical (Cobese Capsules) - Overdosage

Single doses of 800 mg of Orlistat (Generic Xenical) and multiple doses of up to 400 mg three times a day for 15 days have been studied in normal weight and obese subjects without significant adverse findings.

Side Effects Of Cobese Capsules (Generic Xenical)

The most common side effects of Cobese Capsules (Generic Xenical) are Oily Spotting, Flatus with Discharge, Fecal Urgency, Fatty/Oily Stool, Oily Evacuation, Increased Defecation and Fecal Incontinence.

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Champix Tablets | Varenicline Tartrate | Dosage | Uses | Side effects

Champix Tablets (Varenicline Tartrate) - Active Ingredient And Chemical structure

The active ingredient contained in Champix Tablets is varenicline tartrate. The structure is shown below

Champix Tablets (Varenicline Tartrate) - Uses

Varenicline Tartrate in the form of Champix Tablets is used to relieve the craving and withdrawal symptoms associated with stopping smoking.

Generic Forms and Brand names of Champix Tablets (Varenicline Tartrate)

Champix Tablets manufactured by Pfizer, India is an effective treatment for help to relieve the craving and withdrawal symptoms associated with stopping smoking. Champix which has the active ingredient varenicline tartrate is also sold as Chantix and under various other brand names.

Champix Tablets - Preparations

Champix Tablets is available as tablets of 0.5 mg and 1 mg.

Champix Tablets - Storage Requirements

Champix Tablets (Varenicline Tartrate) are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.

Champix Tablets Dosage

Day 1 - 3
Take one white Champix 0.5 mg tablet once a day.

Day 4 - 7
Take one white Champix 0.5 mg tablet twice a day, once in the morning and once in the evening, at about the same time each day.

Week 2 (day 8) to the end of treatment: There are two dosing options

Day 8 to end of treatment 0.5 mg twice a day: Continue to take one white Champix 0.5 mg pill in the morning, and one in the evening, at about the same time each day

OR

1.0 mg twice a day

Day 8 to end of treatment

1.0 mg twice a day: Take one light blue CHAMPIX 1.0 mg pill in the morning, and one in the evening, at about the
same time each day

Champix Tablets - Warnings and Precautions

In case you develop any of the below mentioned while undergoing Champix therapy, call your doctor right away:

thoughts about suicide or dying, or attempts to commit suicide
new or worse depression, anxiety or panic attacks
feeling very agitated or restless
acting aggressive, being angry, or violent
acting on dangerous impulses
an extreme increase in activity and talking (mania)
abnormal thoughts or sensations
seeing or hearing things that are not there(hallucinations)
feeling people are against you (paranoia)
feeling confused
other unusual changes in behavior

Tell your doctor if you take: Insulin, Asthma medicines (theophylline) or Blood thinner (warfarin)

An adjustment of the dose of these medicines may be necessary once you are smoke-free.

Champix Tablets - Contraindications

Champix Tablets is contraindicated in individuals with hypersensitivity to varenicline tartrate or any of the other ingredients of the medication.
In Persons using nicotine replacement therapy, such as patches, gum or inhaler.
The combination of Champix Tablets and nicotine replacement therapy is not expected to improve your chances of quitting, and may result in more side effects than with Champix Tablets alone.

Side Effects Of Champix Tablets

Like all medicines, Champix Tablets can cause side effects, although all persons will not get them.The most common side effects of are Nausea, vomiting, Trouble sleeping, Headache, Abnormal dreams (vivid, unusual, or increased dreaming; rarely may include nightmares), Sleepiness, tiredness, dizziness, Constipation, diarrhea, gas.

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A-Ret Gel | Generic Retin-A Cream | Dosage | Uses | Side effects

A-Ret Gel (Generic Retin-A Cream) - Active Ingredient And Chemical structure

The active ingredient contained in A-Ret Gel (Generic Tretinoin Cream) is tretinoin also known as retinoic acid or vitamin A acid in either of two strengths, 0.025% or 0.05% or 0.1% by weight. It is a member of retinoid family of compounds. The structure is shown below

A-Ret Gel ( Generic Retin-A Cream) - Uses

Generic Retin-A Cream in the form of A-Ret Gel is used for the topical application in the treatment of acne vulgaris and on skin that has been damaged by excessive exposure to the sun.

Generic Forms and Brand names of Retin-A Cream

A-Ret Gel manufactured by Shalaks Pharmaceuticals Pvt. Ltd., India is an effective treatment for Acne vulgaris, Photoaging and Melasma. Retin-A Cream which has the active ingredient Tretinoin is also sold as Generic Tretinoin Cream, Retino-A Cream, Renova, Aberela, Avita, Airol, Atralin, Stieva-A, Vesanoid and under various other brand names.

A-Ret Gel - Preparations

A-Ret Gel is available as 20 grams tubes of 0.025% or 0.05% or 0.1% strengths .

A-Ret Gel (Generic Retin-A Cream) - Storage Requirements

A-Ret Gel is to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.

A-Ret Gel (Generic Retin-A Cream) - Dosage

A-Ret Gel should be applied once a day, before bedtime, or as directed by your physician. to the skin where acne lesions appear, using enough to cover the entire affected area lightly. Excessive application of gel results in “pilling” of the gel, which minimizes the likelihood of over application by the patient.
Application may cause a transitory feeling of warmth or slight stinging. In cases where it has been necessary to temporarily discontinue therapy or to reduce the frequency of application, therapy may be resumed or frequency of application increased when the patients become able to tolerate the treatment.
Therapeutic results should be noticed after two to three weeks but more than six weeks of therapy may be required before definite beneficial effects are seen.
Squeeze about a half inch or less of medication onto the fingertip. After you gain some experience with A-Ret Gel you may find you need slightly more or less to do the job. The medication should become invisible almost immediately.
If it is still visible, or if dry flaking occurs from the gel within a minute or so, you are using too much. Cover the affected area lightly with A-Ret Gel (tretinoin) by first dabbing it on your forehead, chin and both cheeks, then spreading it over the entire affected area. Smooth gently into the skin.

A-Ret Gel (Generic Retin-A Cream) - Overdose

If A-Ret Gel is applied excessively, rapid or better results will be not be obtained. However marked redness, peeling, or discomfort may occur. Oral ingestion of Generic Retin-A Cream may lead to the same side effects as those associated with excessive oral intake of Vitamin A.

A-Ret Gel (Generic Retin-A Cream) - Contraindications

A-Ret Gel is contraindicated in patients that have a hypersensitivity to Tretinoin or any inactive ingredient present in A-Ret Gel.

Side Effects Of A-Ret Gel (Generic Retin-A Cream)

The most common side effects of A-Ret Gel which may occur in certain sensitive individuals is that the skin may become excessively red, edematous, blistered, or crusted.
If these effects occur, the medication should either be discontinued until the integrity of the skin is restored, or the medication should be adjusted to a level the patient can tolerate. True contact allergy to topical tretinoin is rarely encountered. Hyper- or hypopigmentation of a Temporary nature has been reported with repeated application of Generic Retin-A Cream.
Some individuals have been reported to have heightened susceptibility to sunlight while under treatment with A-Ret Gel. To date, all adverse effects of A-Ret Gel have been reversible upon discontinuance of therapy

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