Acetec Capsules (Generic Soriatane) - Active Ingredient And Chemical structure
The active ingredient contained in Acetec Capsules (Generic Soriatane) is Acitretin, a retinoid. Acitretin is a yellow to greenish-yellow powder with a molecular weight of 326.44. The structure is shown below
Acetec Capsules (Generic Soriatane) - Uses
Generic Soriatane in the form of Acetec Capsules is used to treat severe psoriasis in adults. As there exists significant adverse effects associated with its use, Soriatane should be prescribed only by those knowledgeable in the systemic use of retinoids. In the case of females of reproductive potential,
Soriatane should be administered only to non-pregnant patients who are not responsive to other medications or whose clinical condition contraindicates the use of other treatments.
Generic Forms and Brand names of Soriatane
Acetec Capsules manufactured by Dr Reddy's Laboratories Ltd., India is an effective treatment for severe resistant psoriasis in adults. Soriatane which has the active ingredient Acitretin is also sold as Generic Acitretin, Soriatane, Aceret or Acitrin and under various other brand names.
Acetec Capsules - Preparations
Acetec is available as Capsules of 10 mg and 25 mg for oral administration.
Acetec Capsules (Generic Soriatane) - Storage Requirements
Acetec Capsules (Generic Soriatane) are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.
Acetec Capsules (Generic Soriatane) - Contraindications
Generic Soriatane must not be used by females who are pregnant, or who intend to become pregnant during therapy or at any time for at least 3 years following discontinuation of therapy.
Acetec Capsules (Generic Soriatane) is contraindicated in patients with severely impaired liver or kidney function and in patients with chronic abnormally elevated blood lipid values. An increased risk of hepatitis has been reported to result from combined use of methotrexate and etretinate. Consequently, the combination of methotrexate with Generic Soriatane is also contraindicated.
Similarly both Soriatane and tetracyclines can cause increased intracranial pressure, their combined use is contraindicated. Acetec Capsules (Generic Soriatane) is contraindicated in cases of hypersensitivity to acitretin or any inactive ingredient present in the medication or to other retinoids.
Acetec Capsules (Generic Soriatane) - Dosage
Acetec Capsules therapy should be initiated for adults at 25 to 50 mg per day, given as a single dose with the main meal. Maintenance doses of 25 to 50 mg per day may be given dependent upon an individual patient’s response to initial treatment. Relapses may be treated as outlined for initial therapy.
Side Effects Of Acetec Capsules (Generic Soriatane)
Hypervitaminosis A produces a wide spectrum of signs and symptoms primarily of the mucocutaneous, musculoskeletal, hepatic, neuropsychiatric, and central nervous systems. Many of the clinical adverse reactions reported to date with Generic Soriatane administration resemble those of the hypervitaminosis A syndrome. The side effects of Acetec Capsules (Generic Soriatane) are listed below:
Cardiovascular: Acute myocardial infarction, thromboembolism, stroke
Nervous System: Myopathy with peripheral neuropathy has been reported during Soriatane therapy. Both conditions improved with discontinuation of the drug.
Psychiatric: Aggressive feelings and/or suicidal thoughts have been reported. These events, including self-injurious behavior, have been reported in patients taking other systemically administered retinoids, as well as in patients taking Soriatane.
Reproductive: Vulvo-vaginitis due to Candida albicans
Skin and Appendages: Thinning of the skin, skin fragility and scaling may occur all over the body, particularly on the palms and soles; nail fragility is frequently observed.
The other reported side effects include:
Central Nervous System
Rigors
Eye Disorders
Xerophthalmia
Mucous Membranes
Cheilitis, Rhinitis, Dry mouth, Epistaxis
Musculoskeletal
Arthralgia
Spinal hyperostosis(progression of existing lesions)
Skin and Appendages
Alopecia, Dry skin, Erythematous rash, Skin peeling, Nail disorder, Hyperesthesia, Pruritus, Paresthesia, Paronychia,Skin atrophy, Sticky skin
