E2 Vaginal Tablets (Generic Vagifem Pessaries) - Active Ingredient And Chemical structure
The active ingredient contained in Generic Vagifem Pessaries is Estradiol ( also referred to as oestradiol). Oestradiol which is in Vagifem is a natural type of oestrogen. Estradiol hemihydrate is a white, almost white or colorless crystalline solid. The structure is shown below
E2 Vaginal Tablets (Generic Vagifem) - Uses
Generic Vagifem in the form of E2 Vaginal Tablets is used for the treatment of certain vaginal symptoms which occur after menopause, such as dryness, itchiness and pain during sexual intercourse. This is caused by a drop in the level of a hormone called oestrogen. However, your doctor may prescribe this medicine for another use.
Generic Forms and Brand names of Vagifem Pessaries
E2 Vaginal Tablets manufactured by Sun Pharmaceuticals Ltd., India is an effective treatment for vaginal conditions caused by menopause or a deficiency of estrogen hormone. Vagifem which has the active ingredient Estradiol is also sold as Vagifem Suppository, Estradiol, Estrace, Estring, Femring, Estring Ring and under various other brand names.
E2 Vaginal Tablets - Preparations
E2 Vaginal Tablets are available as tablets of 2 mg.
E2 Vaginal Tablets (Generic Vagifem) - Contraindications
E2 Vaginal Tablets (Generic Vagifem) should not be used in women with any of the following conditions:
(1)Known allergy to oestradiol or any inactive ingredient present in Generic Vagifem
(2)Undiagnosed abnormal genital bleeding
(3)Known, suspected, or history of breast cancer
(4)Known or suspected estrogen-dependent neoplasia
(5)Active deep vein thrombosis, pulmonary embolism or history of these conditions
(6)Active arterial thromboembolic disease (for example, stroke, and myocardial infarction), or a history of these conditions
(7)Known liver dysfunction or disease
(8) Known or suspected pregnancy
E2 Vaginal Tablets (Generic Vagifem) - Storage Requirements
E2 Vaginal Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.
E2 Vaginal Tablets (Generic Vagifem) - Warnings and Precautions
The warnings and precautions to be taken when using E2 Vaginal Tablets (Generic Vagifem) are given below:
Estrogens increase the risk of gallbladder disease
Discontinue estrogen if severe hypercalcemia, loss of vision, severe hypertriglyceridemia or cholestatic jaundice occurs
The Vagifem applicator may cause vaginal abrasion
Monitor thyroid function in women on thyroid replacement therapy
E2 Vaginal Tablets (Generic Vagifem) - Dosage
E2 Vaginal Tablets (Generic Vagifem) should be administered intravaginally. The recommended dose is 1 tablet daily for 2 weeks, followed by 1 tablet twice weekly.
Side Effects Of E2 Vaginal Tablets (Generic Vagifem)
The most common side effects of E2 Vaginal Tablets (Generic Vagifem) with an incidence rate of 5% or greater are upper respiratory tract infection, headache, abdominal pain, back pain, genital pruritis, moniliasis, vulvovaginal mycotic infection and diarrhea.
