Chloromycetin Aplicaps (Chloramphenicol Eye Ointment) - Active Ingredient And Chemical structure
The active ingredient contained in Chloromycetin Aplicaps is Chloramphenicol. Chloramphenicol is a white to greyish-white or yellowish-white, fine crystalline powder or fine crystals, needles or elongated plates. It is soluble to the extent of 1 in 400 of water, 1 in 2.5 of alcohol, and 1 in 7 of propylene glycol; freely soluble in acetone and ethyl acetate; slightly soluble in ether. The structure is shown below
Chloromycetin Aplicaps (Chloramphenicol Eye Ointment) - Uses
Chloramphenicol Eye Ointment in the form of Chloromycetin is a topical antibiotic preparation for the treatment of bacterial conjunctivitis.
Generic Forms and Brand names of Chloramphenicol Eye Ointment
Chloromycetin Aplicaps manufactured by Pfizer Ltd., India is an effective treatment for Ocular bacterial infections caused by organisms susceptible to chloramphenicol.
Chloromycetin Aplicaps - Preparations
Chloromycetin is available as aplicaps of 250 mg. Each Aplicap contains 250 mg of chloramphenicol eye ointment I.P. (1%) in an oleaginous ointment base.
Chloromycetin Aplicaps (Chloramphenicol Eye Ointment) - Storage Requirements
Chloromycetin Aplicaps are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.
Chloromycetin Aplicaps (Chloramphenicol Eye Ointment) - Dosage
To use Chloramphenicol Eye Ointment , wipe the tip of the the aplicap with alcohol, cut the end with a clean instrument and compress the body to squeeze out the contents. Apply the Chloramphenicol Eye ointment, to the affected eye by placing in the lower conjunctival sac every 3 hours or more frequently if necessary. Continue administration day and night for the first 48 hours, at which time the frequency of application can be decreased. Treatment should be continued for at least 48 hours after the eye appears normal.
Chloromycetin Aplicaps (Chloramphenicol Eye Ointment) - Contraindications
Chloromycetin Aplicaps eye ointment is contraindicated in individuals with a history of hypersensitivity and/or toxic reaction to chloramphenicol or any inactive ingredient present in the medication.
Side Effects Of Chloromycetin Aplicaps (Chloramphenicol Eye Ointment)
Blood dyscrasias have been reported in association with the use of Chloromycetin Aplicaps. Chloramphenicol is absorbed systemically from the eye, and toxicity has been reported following chronic exposure. Dose-related toxicity following a single ocular exposure is unlikely.The most common side effects with Chloramphenicol Eye Ointment are Local irritation which includes subjective symptoms of itching or burning.
More Serious side effects such as angioneurotic oedema, anaphylaxis, urticaria, fever, vesicular and maculopapular dermatitis have been reported in patients sensitive to chloramphenicol. Discontinue promptly if any serious side effects occur.
