Emeset Tablets (Generic Zofran) - Active Ingredient And Chemical structure
The active ingredient contained in Emeset Tablets is Ondansetron Hydrochloride Dihydrate. Ondansetron HCl Dihydrate is a white to off-white powder that is soluble in water and normal saline.The structure is shown below
Generic Forms and Brand names of Zofran (Ondansetron HCl Dihydrate)
Emeset Tablets manufactured by Cipla Ltd., India is an effective treatment for prevention of nausea and vomiting associated with cancer chemotherapy and radiotherapy in patients. It is also used for the prevention of postoperative nausea and/or vomiting. Zofran which has the active ingredient Ondansetron Hydrochloride Dihydrate is also sold as Zuplenz, Emetron, Emodan, Ondemet, Setronax Ondavell and under various other brand names.
Emeset Tablets (Ondansetron HCl Dihydrate) - Preparations
Emeset Tablets is available as tablets of 4 mg and 8 mg . Each film coated tablet contains Ondansetron hydrochloride dihydrate Equivalent to 4 mg and 8 mg of Ondansetron respectively.
Emeset Tablets (Generic Zofran) - Uses
Zofran (Ondansetron HCl Dihydrate) in the form of Emeset Tablets is used to:
1.Prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy.
2.Prevention of nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer hemotherapy.
3.Prevention of nausea and vomiting associated with radiotherapy in patients receiving either total body irradiation, single high-dose fraction to the abdomen, or daily fractions to the abdomen.
4.Prevention of postoperative nausea and/or vomiting. As with other antiemetics, routine prophylaxis is not recommended for patients in whom there is little expectation that nausea and/or vomiting will occur postoperatively. In patients where nausea and/or vomiting must be avoided postoperatively, Emeset Tablets are recommended even where the incidence of postoperative nausea and/or vomiting is low.
Emeset Tablets (Generic Zofran) - Storage Requirements
Emeset Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.
Emeset Tablets - Dosage
The recommended dosage for the treatment of various indications is given below:
1. Prevention of Nausea and Vomiting Associated With Highly Emetogenic Cancer Chemotherapy.
The recommended adult oral dosage of Emeset is 24 mg given as three 8-mg tablets administered 30 minutes before the start of single-day highly emetogenic chemotherapy, including cisplatin >= 50 mg/m 2 .
2.Prevention of Nausea and Vomiting Associated With Moderately Emetogenic Cancer Chemotherapy
The recommended adult oral dosage is one 8-mg Emeset Tablet given twice a day. The first dose should be administered 30 minutes before the start of emetogenic chemotherapy, with a subsequent dose 8 hours after the first dose. One 8-mg EMESET Tablet should be administered twice a day (every 12 hours) for 1 to 2 days after completion of chemotherapy.
3.Prevention of Nausea and Vomiting Associated With Radiotherapy, Either Total Body Irradiation, or Single High-Dose Fraction or Daily Fractions to the Abdomen
The recommended oral dosage is one 8-mg Emeset Tablet given 3 times a day.
For total body irradiation , one 8-mg Emeset Tablet should be administered 1 to 2 hours before each fraction of radiotherapy administered each day.
4.Postoperative Nausea and Vomiting (PONV)
The recommended dosage is 16 mg given as two 8 mg Emeset Tablets 1 hour before induction of anesthesia.
Side Effects Of Emeset Tablets (Generic Zofran)
The most common side effects of Emeset Tablets are Headache, Malaise/fatigue,Constipation, Diarrhea and Dizziness.
