Crestor Tablets (Rosuvastatin Calcium) - Active Ingredient And Chemical structure
Crestor (Rosuvastatin Calcium) is a synthetic lipid-lowering agent for oral administration. The active ingredient contained in Crestor is Rosuvastatin Calcium. Rosuvastatin calcium is a white amorphous powder that is sparingly soluble in water and methanol, and slightly soluble in ethanol. The structure is shown below
Generic Forms and Brand names of Crestor Tablets (Rosuvastatin Calcium)
Crestor Tablets manufactured by Astra Zeneca, India is an effective treatment to slow down the production of cholesterol in the body and to prevent cardiovascular disease.
Crestor Tablets (Rosuvastatin Calcium) - Preparations
Crestor is available as tablets of 5 mg, 10 mg and 20 mg.
Crestor Tablets (Rosuvastatin Calcium) - Storage Requirements
Crestor Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.
Crestor Tablets (Rosuvastatin Calcium) - Uses
Rosuvastatin Calcium in the form of Crestor Tablets is used to treat the below mentioned indications:
Hyperlipidemia and Mixed Dyslipidemia
Crestor is indicated as adjunctive therapy to diet to reduce elevated Total-C, LDL-C, ApoB, nonHDL-C, and triglycerides and to increase HDL-C in adult patients with primary hyperlipidemia or mixed dyslipidemia.
Hypertriglyceridemia
Crestor is indicated as adjunctive therapy to diet for the treatment of adult patients with hypertriglyceridemia
Primary Dysbetalipoproteinemia (Type III Hyperlipoproteinemia)
Crestor is indicated as an adjunct to diet for the treatment of patients with primary dysbetalipoproteinemia (Type III Hyperlipoproteinemia).
Homozygous Familial Hypercholesterolemia
Crestor is indicated as adjunctive therapy to other lipid-lowering treatments (e.g., LDL apheresis) or alone if such treatments are unavailable to reduce LDL-C, Total-C, and ApoB in adult patients with homozygous familial hypercholesterolemia.
Slowing of the Progression of Atherosclerosis
Crestor is indicated as adjunctive therapy to diet to slow the progression of atherosclerosis in adult patients as part of a treatment strategy to lower Total-C and LDL-C to target levels.
Crestor Tablets (Rosuvastatin Calcium) - Dosage
The recommended dose range for Crestor is 5 to 40 mg orally once daily. Crestor can be administered as a single dose at any time of day, with or without food.
Hyperlipidemia, Mixed Dyslipidemia, Hypertriglyceridemia, Primary Dysbetalipoproteinemia (Type III Hyperlipoproteinemia) and Slowing of the Progression of Atherosclerosis
The recommended starting dose of Crestor is 10 mg once daily. For patients with marked hyperlipidemia (LDL-C > 190 mg/dL) and aggressive lipid targets, a 20 mg starting dose may be considered.
Homozygous Familial Hypercholesterolemia
The recommended starting dose of Crestor is 20 mg once daily.
Crestor Tablets (Rosuvastatin Calcium) - Contraindications
Crestor is contraindicated in patients with a known hypersensitivity to Rosuvastatin Calcium or any inactive component of this medication.
Side Effects Of Crestor Tablets (Rosuvastatin Calcium)
The most common side effects of are headache, myalgia, abdominal pain, asthenia and nausea. Serious side effects include Rhabdomyolysis with myoglobinuria, acute renal failure, myopathy and Liver enzyme abnormalities.
