Thursday, September 29, 2011

Voveran Tablets | Generic Voltaren | Diclofenac Sodium | Dosage | Uses | Side effects

Voveran Tablets (Generic Voltaren) - Active Ingredient And Chemical structure

Voveran (diclofenac sodium enteric-coated tablets) is a benzene-acetic acid derivative. Voltaren is available as delayed-release (enteric-coated) tablets of 75 mg for oral administration.The active ingredient contained in Voveran is Diclofenac sodium . The structure is shown below

Structure Of Diclofenac Sodium

Generic Forms and Brand names of Voltaren (Diclofenac Sodium)

Voveran Tablets manufactured by Novartis, India is is used as an analgesic to treat pain, inflammatory disorders, and dysmenorrhea. Voltaren which has the active ingredient Diclofenac Sodium is also sold as oltaren delo, Voltarol Pain-eze, Voltaren Rapin, Voltaren T, Diclofenac T, Diclofenac-Asteria, Diclofenaco Normon, Morbidic, Voltaflam, Votrex, Cataflam, Abitren, Zipsor and under various other brand names.

Voveran Tablets - Preparations

Voveran is available as tablets of 50 mg and 100 mg .

Voveran Tablets - Storage Requirements

Voveran Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.

Voveran Tablets (Generic Voltaren) - Uses

Generic Voltaren in the form of Voveran Tablets is used to treat the following indications:
Relief of the signs and symptoms of osteoarthritis
Relief of the signs and symptoms of rheumatoid arthritis
For acute or long-term use in the relief of signs and symptoms of ankylosing spondylitis

Voveran Tablets - Contraindications

Voveran Tablets are contraindicated in patients with known hypersensitivity to diclofenac sodium. Voveran should not be given to patients who have experienced asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients. Voveran is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.

Voveran Tablets - Dosage

The individual patients dosage should be adjusted after observing the response to initial therapy with Voveran Tablets. For the relief of osteoarthritis, the recommended dosage is 100-150 mg/day in divided doses (50 mg twice a day or thrice a day, or 75 mg twice a day).
For the relief of rheumatoid arthritis, the recommended dosage is 150-200 mg/day in divided doses (50 mg thrice a day or four times a day, or 75 mg twice a day). For the relief of ankylosing spondylitis, the recommended dosage is 100-125 mg/day, administered as 25 mg four times a day, with an extra 25-mg dose at bedtime if necessary.

Side Effects Of Voveran Tablets (Generic Voltaren)

The most common side effects of Voveran Tablets (diclofenac sodium) or other NSAIDs occurring in approximately 1%-10% of patients are Gastrointestinal experiences including: abdominal pain, constipation, diarrhea, dyspepsia, flatulence, gross bleeding/perforation, heartburn, nausea, GI ulcers (gastric/duodenal) and vomiting.Abnormal renal function, anemia, dizziness, edema, elevated liver enzymes, headaches, increased bleeding time, pruritus, rashes and tinnitus. Less common side effects that may occur occasionally include:
Body as a Whole: fever, infection, sepsis
Cardiovascular System: congestive heart failure, hypertension, tachycardia, syncope
Digestive System: dry mouth, esophagitis, gastric/peptic ulcers, gastritis, gastrointestinal bleeding, glossitis, hematemesis, hepatitis, jaundice
Hemic and Lymphatic System: ecchymosis, eosinophilia, leukopenia, melena, purpura, rectal bleeding, stomatitis, thrombocytopenia
Metabolic and Nutritional: weight changes
Nervous System: anxiety, asthenia, confusion, depression, dream abnormalities, drowsiness, insomnia, malaise, nervousness, paresthesia, somnolence, tremors, vertigo
Respiratory System: asthma, dyspnea
Skin and Appendages: alopecia, photosensitivity, sweating increased
Special Senses: blurred vision
Urogenital System: cystitis, dysuria, hematuria, interstitial nephritis, oliguria/polyuria, proteinuria, renal failure
Other adverse reactions, which occur rarely are:
Body as a Whole: anaphylactic reactions, appetite changes, death
Cardiovascular System: arrhythmia, hypotension, myocardial infarction, palpitations, vasculitis
Digestive System: colitis, eructation, fulminant hepatitis with and without jaundice, liver failure, liver necrosis, pancreatitis
Hemic and Lymphatic System: agranulocytosis, hemolytic anemia, aplastic anemia, lymphadenopathy, pancytopenia
Metabolic and Nutritional: hyperglycemia
Nervous System: convulsions, coma, hallucinations, meningitis
Respiratory System: respiratory depression, pneumonia
Skin and Appendages: angioedema, toxic epidermal necrolysis, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, urticaria
Special Senses: conjunctivitis, hearing impairment

Symptoms And Treatment Of Voveran Tablets (Generic Voltaren) Overdose

Symptoms following acute Voveran Tablets or other NSAID overdoses are usually limited to lethargy, drowsiness, nausea,vomiting, and epigastric pain, which are generally reversible with supportive care. Gastrointestinal bleeding can occur. Hypertension, acute renal failure, respiratory depression and coma may occur, but are rare. Anaphylactoid reactions have been reported with therapeutic ingestion of NSAIDs, and may occur following an overdose.
Patients should be managed by symptomatic and supportive care following a NSAID overdose. There are no specific antidotes. Emesis and/or activated charcoal (60 to 100 g in adults, 1 to 2 g/kg in children) and/or osmotic cathartic may be indicated in patients seen within 4 hours of ingestion with symptoms or following a large overdose (5 to 10 times the usual dose).

Further Information

Prescribing Information