Acetylsalicylic Acid (Aspirin) - Active Ingredient And Chemical structure
The active ingredient contained in Aspirin is Acetylsalicylic Acid. Acetylsalicylic Acid (Aspirin) is an odorless white, needle like crystalline substance. The structure is shown below
Generic Forms and Brand names of Aspirin
Ecosprin Tablets manufactured by USV Ltd. , India is used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. Besides these there are several other uses of Ecosprin Tablets (Generic Aspirin) as detailed below. Aspirin which has the active ingredient Acetylsalicylic Acid is also sold as Ecospr, Ecotrin and many others and under various other brand names.
Ecosprin Tablets - Preparations
Ecosprin Tablets (Generic Aspirin) is available as tablets of 75 mg, 150 mg and 325 mg.
Ecosprin Tablets (Generic Aspirin) - Storage Requirements
Ecosprin Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light. Keep away from children.
Ecosprin Tablets (Generic Aspirin) - Uses
Generic Aspirin in the form of Ecosprin Tablets is used to treat Vascular Indications, to treat patients who have undergone revascularization procedures when there Is a preexisting condition for which aspirin is already indicated and Rheumatologic Disease Indications. Generic Aspirin is also used for the relief of the signs and symptoms of rheumatoid arthritis, juvenile rheumatoid arthritis, osteoarthritis, spondyloarthropathies, and arthritis and pleurisy associated with SLE. Ecosprin is used as an analgesic for rapid relief of minor to moderate aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.
Ecosprin Tablets (Generic Aspirin) - Contraindications
Allergy:Aspirin is contraindicated in patients with known allergy to nonsteroidal anti-inflammatory drug products and in patients with the syndrome of asthma, rhinitis, and nasal polyps. Aspirin may cause severe urticaria, angloedema, or bronchospasm (asthma).
Due to its effect on the stomach lining, patients with peptic ulcers, mild diabetes, or gastritis are recommended to seek medical advice before using aspirin. Persons with hemophilia or any other bleeding tendencies should not take aspirin or other salicylates.
Reye's Syndrome: Reye's syndrome, a rare but severe illness can occur when children or adolescents are given aspirin for a fever or other illnesses or other viral infections. This disease has been most commonly seen to occur when children or adolescents with a respiratory infection, chickenpox, or diarrhea are administered aspirin.
Warnings and Precautions while using Ecosprin Tablets (Generic Aspirin)
Patients who consume three or more alcoholic drinks every day should be counseled about the bleeding risks involved with chronic, heavy alcohol use while taking aspirin. Even low doses of aspirin can inhibit platelet function leading to an increase in bleeding time. Gastrointestinal Side Effects include stomach pain, heartburn, nausea, vomiting, and gross Gastro Intestinal bleeding. Persons with a history of active peptic ulcer disease should avoid using aspirin, which can cause gastric mucosal irritation and bleeding.
Please consult your doctor if you have any medical history or have certain allergies or suffer from any ailment or condition.
Ecosprin Tablets (Generic Aspirin) - Dosage
Patients should take each dose of aspirin with a full glass of water unless the patient is fluid restricted. The normal adult Anti-inflammatory and analgesic dosage is 325 mg every 4 hours (Varies as per individual). For some other indications the normal adult is given below. Please consult your doctor for exact dosing instructions.
Ischemic Stroke and TIA: 50-325 mg once a day. Continue therapy indefinitely.
Suspected Acute MI: The initial dose of 160-162.5 mg is administered as soon as an MI is suspected. The maintenance dose of 160-162.5 mg a day is continued for 30 days post-infarction. After 30 days, consider further therapy based on dosage and administration for prevention of recurrent MI.
Prevention of Recurrent MI: 75-325 mg once a day. Continue therapy indefinitely.
Unstable Angina Pectoris: 75-325 mg once a day. Continue therapy indefinitely.
Chronic Stable Angina Pectoris:75-325 mg once a day. Continue therapy indefinitely.
CABG: 325 mg daily starting 6 hours post-procedure. Continue therapy for one year post-procedure.
PTCA: The initial dose of 325 mg should be given 2 hours pre-surgery. Maintenance dose is 160-325 mg daily. Continue therapy indefinitely.
Carotid Endarterectomy: Doses of 80 mg once daily to 650 mg twice daily, started pre-surgery, are recommended.Continue therapy indefinitely.
Rheumatoid Arthritis: The initial dose is 3 g a day in divided doses. Increase as needed for anti-inflammatory efficacy with target plasma salicylate levels of 150-300 mcg/mL.
Juvenile Rheumatoid Arthritis: Initial dose is 90-130 mg/kg/day in divided doses. Increase as needed for anti-inflammatory efficacy with target plasma salicylate levels of 150-300 mcg/mL.
Spondyloarthropathies: Up to 4 g per day in divided doses.
Osteoarthritis: Up to 3 g per day in divided doses.
Arthritis and Pleurisy of SLE: The initial dose is 3g a day in divided doses. Increase as needed for anti-inflammatory efficacy with target plasma salicylate levels of 150-300 mcg/mL.
Side Effects Of Ecosprin Tablets (Generic Aspirin)
Many side effects of Ecosprin Tablets are dose-related. The following is a list of adverse reactions that have been reported:
Body as a Whole: Fever, hypothermia, thirst.
Cardiovascular: Dysrhythmias, hypotension/ tachycardia.
Central Nervous System: Agitation, cerebral edema, coma, confusion, dizziness, headache,subdural or intracranial hemorrhage, lethargy, seizures.
Fluid and Electrolyte: Dehydration, hyperkalemia, metabolic acidosis, respiratory alkalosis.
Gastrointestinal: Dyspepsia, GI bleeding, ulceration and perforation, nausea, vomiting, transient elevations of hepatic enzymes, hepatitis, Reye's syndrome, pancreatitis.
Hematologic: Prolongation of the prothrombin time, disseminated intravascular coagulation, coagulopathy, thrombocytopenia.
Hypersensitivity: Acute anaphylaxis, angioedema, asthma, bronchospasm, laryngeal edema, urticaria.
Musculoskeletal: Rhabdomyolysis.
Metabolism: Hypoglycemia (in children), hyperglycemia.
Reproductive: Prolonged pregnancy and labor, stillbirths, lower birth weight infants, antepartum and postpartum bleeding.
Respiratory: Hyperpnea, pulmonary edema, tachypnea.
Special Senses: Hearing loss, tinnitus. Patients with higher frequency hearing loss may have difficulty perceiving tinnitus. In these patients, tinnitus cannot be used as a clinical indicator of salicylism
Urogenital: Interstitial nephritis, papillary necrosis, proteinuria, renal insufficiency and failure.
