Wednesday, July 13, 2011

Generic Tamoxifen Tablets | Tamtero | Nolvadex Tablets | Dosage | Uses | Side effects

Generic Tamoxifen Tablets - Active Ingredient And Chemical structure

The active ingredient contained in Generic Tamoxifen Tablets (also referred to as generic Nolvadex) is Tamoxifen Citrate. The structure is shown below

Structure  Of Tamoxifen Citrate

Generic Forms and Brand names of Nolvadex Tablets

Although Tamoxifen was discovered by ICI Pharmaceuticals (presently AstraZeneca) and is sold under the brand names Nolvadex, Istubal, and Valodex, the medication is still is widely referred to by its generic name "tamoxifen". Tamtero manufactured by Hetero Drugs Ltd, India is effective for treatment and prevention of breast cancer in men and women. Tamtero Tablets (tamoxifen citrate) Tablets, a nonsteroidal antiestrogen, are for oral administration. Generic Tamoxifen which has the active ingredient Tamoxifen Citrate is also sold as Istubal, Valodex, Tamoxifen Apo-Tamox; Gen-Tamoxifen, Novo-Tamoxifen, Tamofen, Tamone, Citofen, Crisafeno, Diemon, Istubol, Kessar, Noltam, Nourytam, Novo-Tamoxifen , Oncomox, PMS-Tamoxifen, Tamoxifene, Tamoxifen, Retaxim, Tamizam, Tamoxasta, Tamoxen, Valodex, Zemide, Tamoxifeno, Soltamox and under various other brand names.

Generic Tamoxifen Preparations

Generic Tamoxifen is available as Tamtero tablets of 10 mg. Each 10 mg tablet of Tamtero contains 15.2 mg of tamoxifen citrate which is equivalent to 10 mg of tamoxifen.

Generic Tamoxifen Tablets (Tamtero) - Storage Requirements

Tamtero Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.

Generic Tamoxifen Tablets (Tamtero) - Uses

Generic Tamoxifen Tablets in the form of Tamtero Tablets is used to treat metastatic breast cancer adjuvant treatment of breast cancer, ductal carcinoma in situ as well as for reduction in breast cancer incidence in high risk women.
Metastatic Breast Cancer:
Generic Tamoxifen Tablets are effective in the treatment of metastatic breast cancer in women and men. In premenopausal women with metastatic breast cancer, Tamtero is an alternative to oophorectomy or ovarian irradiation.
Adjuvant Treatment of Breast Cancer:
Generic Tamoxifen Tablets are indicated for the treatment of node-positive breast cancer in postmenopausal women following total mastectomy or segmental mastectomy, axillary dissection, and breast irradiation.
Ductal Carcinoma in Situ (DCIS):
In women with DCIS, following breast surgery and radiation, Generic Tamoxifen Tablets are used to reduce the risk of invasive breast cancer
Reduction in Breast Cancer Incidence in High Risk Women:
Generic Tamoxifen Tablets are used to reduce the incidence of breast cancer in women at high risk for breast cancer.

Tamtero Tablets (Generic Tamoxifen) - Contraindications

Generic Tamoxifen is contraindicated in patients with known hypersensitivity to the drug or any of its ingredients.

Tamtero Tablets (Generic Tamoxifen) - Dosage

The recommended dosages of Tamtero Tablets (Generic Tamoxifen) are given below;
Breast Cancer:
For patients with breast cancer, the recommended daily dose is 20-40 mg. Dosages more than 20 mg per day should be given in divided doses (morning and evening).
Ductal Carcinoma in Situ (DCIS):
The recommended dose is Tamtero Tablets 20 mg daily for 5 years.
Reduction in Breast Cancer Incidence in High Risk Women:
The recommended dose is Tamtero Tablets 20 mg daily for 5 years.

Side Effects Of Generic Tamoxifen Tablets (Tamtero)

The most common side effects of Generic Tamoxifen Tablets are Hot Flashes, Vaginal Discharges, Vaginal Bleeding, Decreased Platelets count, Infection/Sepsis, Constipation, Alopecia, Allergy. Less frequently reported adverse reactions are vaginal bleeding, vaginal discharge, menstrual irregularities, skin rash and headaches. Most of the time these have not been of sufficient severity to require dosage reduction or discontinuation of treatment. Very rare reports of erythema multiforme, Stevens-Johnson syndrome, bullous pemphigoid, interstitial pneumonitis, hypersensitivity reactions including angioedema have been reported by patients undergoing treatment with Generic Tamoxifen.

Further Information

Prescribing Information