Monday, July 11, 2011

Plagril Tablets | Generic Plavix | Dosage | Uses | Side effects

Generic Plavix (Plagril Tablets) - Active Ingredient And Chemical structure

The active ingredient contained in Plagril Tablets is Clopidogrel Bisulfate. Clopidogrel bisulfate is a white to off-white powder. It is practically insoluble in water. The structure is shown below
Structure of Clopidogrel Bisulfate

Generic Forms and Brand names of Generic Plavix

Plagril manufactured by Dr. Reddy's Pharmaceuticals, India is an effective treatment to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease. Generic Plavix which has the active ingredient Clopidogrel Bisulfate is also sold under various other brand names.

Generic Plavix (Plagril Tablets) - Preparations

Plagril Tablets is available as oral tablets of 75 mg .

Plagril Tablets (Generic Plavix) - Storage Requirements

Plagril Tablets are to be stored at room temperature (15°C to 30°C). Store away from heat, moisture, and light.

Generic Plavix (Plagril Tablets) - Uses

Generic Plavix, a P2Y12 platelet inhibitor in the form of Plagril tablets is used to treat:
Acute coronary syndrome
Patients with non-ST-segment elevation ACS
Patients with ST-elevation myocardial infarction (STEMI)
Recent myocardial infarction (MI), recent stroke, or established peripheral arterial disease.

Plagril Tablets (Generic Plavix) - Dosage

The dosing for Generic Plavix is as follows:
Acute coronary syndrome
- Non-ST-segment elevation ACS (UA/NSTEMI): 300 mg loading dose followed by 75 mg once daily, in combination with aspirin (75-325 mg once daily)
- STEMI: 75 mg once daily, in combination with aspirin (75-325 mg once daily), with or without a loading dose and with or without thrombolytics
Recent MI, recent stroke, or established peripheral arterial disease: 75 mg once daily

Plagril Tablets (Generic Plavix) - Contraindications

Generic Plavix is contraindicated in patients with active pathological bleeding such as peptic ulcer or intracranial hemorrhage. Plagril Tablets are also contraindicated in patients with hypersensitivity to Clopidogrel Bisulfate or any any inactive ingredient of the product.

Side Effects Of Plagril Tablets (Generic Plavix)

The most commonly reported side effects of Plagril Tablets are Bleeding, including life-threatening and fatal bleeding. Less common side effects that may occur are Severe neutropenia (low white blood cells), Thrombotic thrombocytopenic purpura (TTP), skin irritations, respiratory difficulties, bloody stools and vomit, bloating of facial features, limbs and joints, exhaustion.

Further Information

Prescribing Information